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CDKN1A and CCNA1
Data Source:
HPRD
(in vitro)
CDKN1A
CCNA1
Description
cyclin dependent kinase inhibitor 1A
cyclin A1
Image
No pdb structure
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Nuclear Body
Protein-containing Complex
Perinuclear Region Of Cytoplasm
PCNA-p21 Complex
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Microtubule Cytoskeleton
Cyclin A1-CDK2 Complex
Cyclin A2-CDK2 Complex
Molecular Function
Protein Kinase Inhibitor Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Protein Kinase Binding
Cyclin-dependent Protein Kinase Activating Kinase Activity
Cyclin Binding
Ubiquitin Protein Ligase Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Sequestering Activity
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Protein Import Into Nucleus
Cellular Response To DNA Damage Stimulus
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Cell Cycle Arrest
Mitotic G2 DNA Damage Checkpoint
Ras Protein Signal Transduction
Heart Development
Negative Regulation Of Cell Population Proliferation
Response To Toxic Substance
Response To X-ray
Response To Organonitrogen Compound
Negative Regulation Of Gene Expression
Cytokine-mediated Signaling Pathway
Negative Regulation Of Cell Growth
Positive Regulation Of B Cell Proliferation
Animal Organ Regeneration
Cellular Response To Extracellular Stimulus
Negative Regulation Of Protein Binding
Cellular Response To Amino Acid Starvation
Cellular Response To Heat
Wound Healing
Tissue Regeneration
Negative Regulation Of Phosphorylation
Response To Drug
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Kinase Activity
Response To Arsenic-containing Substance
Positive Regulation Of Fibroblast Proliferation
Protein Stabilization
Response To Corticosterone
Response To Hyperoxia
Intestinal Epithelial Cell Maturation
Cellular Response To Ionizing Radiation
Cellular Response To Gamma Radiation
Cellular Response To UV-B
Mitotic Cell Cycle Arrest
Cellular Senescence
Replicative Senescence
Stress-induced Premature Senescence
Intrinsic Apoptotic Signaling Pathway
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Cyclin-dependent Protein Kinase Activity
Positive Regulation Of Cyclin-dependent Protein Kinase Activity
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Cardiac Muscle Tissue Regeneration
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of DNA Biosynthetic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Male Meiosis I
Spermatogenesis
Protein Deubiquitination
Mitotic Cell Cycle Phase Transition
Cell Division
Pathways
SCF(Skp2)-mediated degradation of p27/p21
AKT phosphorylates targets in the cytosol
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Constitutive Signaling by AKT1 E17K in Cancer
Interleukin-4 and Interleukin-13 signaling
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional activation of cell cycle inhibitor p21
The role of GTSE1 in G2/M progression after G2 checkpoint
TFAP2 (AP-2) family regulates transcription of cell cycle factors
Transcriptional regulation by RUNX2
RUNX3 regulates CDKN1A transcription
Transcriptional regulation of granulopoiesis
FOXO-mediated transcription of cell cycle genes
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
STAT5 activation downstream of FLT3 ITD mutants
Signaling by FLT3 fusion proteins
G0 and Early G1
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
Telomere Extension By Telomerase
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Ub-specific processing proteases
Processing of DNA double-strand break ends
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
G2 Phase
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G1/S-Specific Transcription
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A/B1/B2 associated events during G2/M transition
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Drugs
Arsenic trioxide
Diseases
Cervical cancer
GWAS
Atrial fibrillation (
30061737
29892015
)
Colorectal cancer (
22634755
30529582
31826910
)
Colorectal cancer or advanced adenoma (
30510241
)
Coronary artery disease (
29212778
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Electrocardiographic conduction measures (
23463857
)
Electrocardiographic traits (
32602732
20062063
)
Glaucoma (primary open-angle) (
29891935
)
Heart failure (
31919418
)
Ischemic stroke (
29531354
)
JT interval (
29874175
)
Left ventricular fractional shortening (
28394258
)
PR interval (
32439900
)
Pulse pressure (
30224653
30578418
)
QRS complex (Cornell) (
27659466
)
QRS duration (
30679814
27577874
31251759
25035420
31217584
21076409
27659466
)
Triglyceride levels (
32203549
)
Triglycerides (
27036123
)
Cocaine dependence (
31212010
)
Nickel levels (
26025379
)
Interacting Genes
205 interacting genes:
A1BG
A2M
ABL1
ACTB
ACTL6B
ADAMTS10
AKT1
AKT2
ALAS1
ANGPT2
APLP1
APP
ATP5F1B
ATP6V1A
ATXN3
BAD
BAG6
BCCIP
CASP3
CCDC85B
CCN3
CCNA1
CCNA2
CCNB1
CCNB2
CCND1
CCND2
CCND3
CCNE1
CCNE2
CCT7
CDC45
CDC5L
CDC6
CDC7
CDK1
CDK14
CDK2
CDK3
CDK4
CDK6
CEBPA
CELF3
CENPB
CHEK2
CHGB
CIZ1
CLEC3B
COL4A5
COPS6
CPNE2
CPNE6
CSAD
CSNK2A1
CSNK2B
CTSB
CZIB
DAPK3
DCAF11
DDAH2
DEAF1
DOCK7
DTL
DYNC1I1
EEF1A1
ESR1
EXT2
F13A1
FAF1
FBN3
FGB
FHL3
FLAD1
FNDC11
GADD45A
GADD45B
GADD45G
GAPDH
GCKR
GDF9
GET4
GMNN
GNB2
GNB5
GOLGA2
H1-5
HADHB
HDAC1
HDAC11
HDAC2
HDAC4
HDAC6
HERC5
HMGXB3
HNRNPK
HOOK2
HOXD8
HPD
IKBKG
IKZF3
INCA1
ING5
INPP5K
KIFC3
KLHL23
KMT2B
KRT31
KRTAP3-1
LATS2
LRIF1
LRP2BP
LRR1
LZTS2
MAP3K5
MAPK8
MCM10
MED31
MEOX2
MSH2
MTUS2
NFYA
NGFR
NKD2
NMRK2
NPRL2
NR1H2
NRBP1
OTUB1
PARP1
PCNA
PDE4DIP
PDHB
PIM1
PKM
POLD2
PRKACA
PRKAR1B
PRKN
PSMA3
PSMC2
QARS1
RAB1A
RACK1
RAI1
RB1
RBBP4
RBM48
REL
RNF126
RNF144B
RPL18
RPL35
RPS2
RRM2B
S100A8
SDF4
SET
SETDB1
SHISA6
SIPA1
SKP1
SKP2
SLC25A11
SP110
SPRED1
STAT3
STAT5B
STUB1
SUMO3
TAF5L
TCF4
TEX11
TFIP11
TK1
TLE1
TMSB4X
TNIP1
TNIP2
TP53
TRAF1
TRIM3
TRIM54
TRMT2A
TSG101
TTLL5
TUBA1A
TUBB2B
TUBB3
TXN
TXNDC11
UBE2D1
UNC119
USHBP1
USP11
USP4
VIM
VPS51
WDR73
WIZ
XRCC6
YWHAQ
ZBTB16
ZBTB48
ZNF135
ZNF431
35 interacting genes:
ARID2
BRCA1
BRCA2
CABLES1
CDC20
CDC25A
CDK1
CDK2
CDKN1A
CDKN1B
CKS1B
CKS2
CUX1
E2F1
GPS2
H1-1
H1-5
H2BC1
INCA1
KLHDC9
MCM4
MCM6
MYBL2
NPAT
PGR
PROCA1
RACK1
RB1
RBL1
RBL2
RBM4
RPA1
SP1
SRC
XRCC6
Entrez ID
1026
8900
HPRD ID
00298
04946
Ensembl ID
ENSG00000124762
ENSG00000133101
Uniprot IDs
A0A024RCX5
P38936
A0A140VJG0
P78396
PDB IDs
1AXC
2ZVV
2ZVW
4RJF
5E0U
6CBI
6CEJ
6CIV
6CIX
6P8H
Enriched GO Terms of Interacting Partners
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