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TNK2 and CTTN
Data Source:
BioGRID
(enzymatic study, affinity chromatography technology)
TNK2
CTTN
Description
tyrosine kinase non receptor 2
cortactin
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Clathrin-coated Pit
Adherens Junction
Membrane
Clathrin-coated Vesicle
Cytoplasmic Vesicle Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Perinuclear Region Of Cytoplasm
Grb2-EGFR Complex
Cytoophidium
Ruffle
Podosome
Cytoplasm
Golgi Apparatus
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Clathrin-coated Pit
Focal Adhesion
Cell Cortex
Voltage-gated Potassium Channel Complex
Lamellipodium
Growth Cone
Site Of Polarized Growth
Cortical Cytoskeleton
Cortical Actin Cytoskeleton
Dendritic Spine
Intracellular Membrane-bounded Organelle
Mitotic Spindle Midzone
Molecular Function
Protein Serine/threonine/tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
GTPase Inhibitor Activity
Signaling Receptor Binding
Epidermal Growth Factor Receptor Binding
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Metal Ion Binding
WW Domain Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Protein Binding
Profilin Binding
Cadherin Binding
Actin Filament Binding
Biological Process
Endocytosis
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Small GTPase Mediated Signal Transduction
Phosphorylation
Cell Differentiation
Negative Regulation Of GTPase Activity
Innate Immune Response
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Clathrin-dependent Endocytosis
Intracellular Protein Transport
Receptor-mediated Endocytosis
Substrate-dependent Cell Migration, Cell Extension
Actin Filament Polymerization
Regulation Of Axon Extension
Regulation Of Actin Filament Polymerization
Positive Regulation Of Actin Filament Polymerization
Actin Cytoskeleton Reorganization
Positive Regulation Of Smooth Muscle Contraction
Focal Adhesion Assembly
Neuron Projection Morphogenesis
Cell Motility
Membrane Organization
Dendritic Spine Maintenance
Lamellipodium Organization
Regulation Of Autophagy Of Mitochondrion
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
RHO GTPases activate PAKs
Clathrin-mediated endocytosis
Drugs
ATP
Debromohymenialdisine
Entrectinib
Fostamatinib
Diseases
GWAS
Asthma (
31959851
)
Bronchopulmonary dysplasia (
23897914
)
Low density lipoprotein cholesterol levels (
30498476
)
Total cholesterol levels (
30498476
)
Interacting Genes
49 interacting genes:
AKT1
AQP1
AR
ARSL
BAG3
CDC42
CLTC
CSPG4
CTTN
CYSRT1
DPH2
EGFR
FGFR1
FYN
GALT
GRB2
HCK
HECW1
HSH2D
HSP90AB2P
ITFG2
KCNA5
KRTAP10-3
MAGI3
MCF2
MERTK
NCK1
NEK6
NOTCH2NLA
NPHP1
PDGFRB
PIK3R3
RASGEF1C
RASGRF1
RPL18A
SEZ6
SH2D1A
SH2D1B
SIAH1
SMURF1
SNX9
SOCS4
SRC
SRSF5
VTI1B
WAS
WWOX
WWP2
YES1
42 interacting genes:
ACD
ACTA1
ACTG1
ACTR3
ANKZF1
ARHGAP17
ARHGAP8
CASP3
CD2AP
CHD3
CTNND1
CTNND2
CTTNBP2
DNM1
DNM2
EGFR
FER
FGD1
GRB2
HAX1
HDAC6
HIP1R
KCNA2
KEAP1
MET
MYLK
NHSL2
RPL9
SDC3
SH3BP2
SHANK2
SIRT1
SMURF1
SPRR2A
SRC
SYK
TINF2
TJP1
TNK2
TRIM15
WASL
WIPF1
Entrez ID
10188
2017
HPRD ID
06104
01268
Ensembl ID
ENSG00000061938
ENSG00000085733
Uniprot IDs
A0A499FJ16
A0A5F9ZGX5
A0A5F9ZHJ2
B3KXJ4
C9J1X3
Q07912
A0A024R5M3
Q14247
Q53HG7
PDB IDs
1CF4
1U46
1U4D
1U54
3EQP
3EQR
4EWH
4HZR
4HZS
4ID7
5ZXB
1X69
2D1X
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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