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NAMPT and AKT2
Data Source:
BioGRID
(two hybrid)
NAMPT
AKT2
Description
nicotinamide phosphoribosyltransferase
AKT serine/threonine kinase 2
Image
GO Annotations
Cellular Component
Cytosol
Nuclear Speck
Cell Junction
Extracellular Exosome
Nucleus
Nucleoplasm
Early Endosome
Cytosol
Plasma Membrane
Cell Cortex
Ruffle Membrane
Protein-containing Complex
Intracellular Membrane-bounded Organelle
Molecular Function
Nicotinate-nucleotide Diphosphorylase (carboxylating) Activity
Cytokine Activity
Protein Binding
Identical Protein Binding
Nicotinamide Phosphoribosyltransferase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Metal Ion Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Signal Transduction
Cell-cell Signaling
Circadian Rhythm
Positive Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Circadian Regulation Of Gene Expression
NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Adipose Tissue Development
Positive Regulation Of Protein Phosphorylation
Glycogen Biosynthetic Process
Glucose Metabolic Process
Regulation Of Translation
Cellular Protein Modification Process
Signal Transduction
Positive Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Carbohydrate Transport
Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane
Positive Regulation Of Glucose Metabolic Process
Positive Regulation Of Mitochondrial Membrane Potential
Peptidyl-serine Phosphorylation
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Positive Regulation Of Vesicle Fusion
Positive Regulation Of Fatty Acid Beta-oxidation
Peripheral Nervous System Myelin Maintenance
Cellular Response To Insulin Stimulus
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Fat Cell Differentiation
Positive Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Glucose Import
Mammary Gland Epithelial Cell Differentiation
Intracellular Protein Transmembrane Transport
Regulation Of Cell Cycle Arrest
Cellular Response To High Light Intensity
Protein Localization To Plasma Membrane
Positive Regulation Of Protein Targeting To Membrane
Activation Of GTPase Activity
Retinal Rod Cell Apoptotic Process
Positive Regulation Of Cell Motility
Pathways
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Nicotinamide salvaging
Activation of BAD and translocation to mitochondria
PIP3 activates AKT signaling
PIP3 activates AKT signaling
Downregulation of ERBB2:ERBB3 signaling
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Activation of AKT2
PDE3B signalling
Inhibition of TSC complex formation by PKB
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
AKT-mediated inactivation of FOXO1A
Deactivation of the beta-catenin transactivating complex
CD28 dependent PI3K/Akt signaling
CTLA4 inhibitory signaling
G beta:gamma signalling through PI3Kgamma
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Association with Co-factors
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entry
RAB GEFs exchange GTP for GDP on RABs
RUNX2 regulates genes involved in cell migration
Regulation of PTEN stability and activity
FLT3 Signaling
Regulation of localization of FOXO transcription factors
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs
GMX1777
Daporinad
N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide
4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
Diseases
Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy
Ovarian cancer
GWAS
Grapefruit juice consumption (
31046077
)
Birth weight (
31043758
)
Cerebrospinal fluid t-tau:AB1-42 ratio (
26252872
)
Cerebrospinal T-tau levels (
26252872
)
Diastolic blood pressure (
28739976
)
Lean body mass (
28552196
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Interacting Genes
5 interacting genes:
ADORA2A
AKT2
FANCA
GGT1
USP49
44 interacting genes:
ABCG8
AKT1
AKT1S1
APOA1
APOB
APP
APPL1
BLVRA
CCL14
CDKN1A
CHUK
CLIP3
ESR1
FOXO4
FSHR
GSK3B
H3C1
HSP90AA1
MEOX2
MTCP1
NAMPT
PDPK1
PICK1
PIP5K1C
PLEKHO1
PNPLA3
POFUT1
POLR1B
PRKDC
RAB3D
REL
SH3RF1
SLC2A4
SNX27
SORBS2
SORBS3
SPRR2A
STEAP4
TCL1A
TCL1B
TMED2
TRIB3
TSC2
XIAP
Entrez ID
10135
208
HPRD ID
09938
01262
Ensembl ID
ENSG00000105835
ENSG00000105221
Uniprot IDs
A0A024R718
P43490
B4DG79
P31751
PDB IDs
2E5B
2E5C
2E5D
2GVG
2GVJ
3DGR
3DHD
3DHF
3DKJ
3DKL
4JNM
4JR5
4KFN
4KFO
4KFP
4L4L
4L4M
4LTS
4LV9
4LVA
4LVB
4LVD
4LVF
4LVG
4LWW
4M6P
4M6Q
4N9B
4N9C
4N9D
4N9E
4O0Z
4O10
4O12
4O13
4O14
4O15
4O16
4O17
4O18
4O19
4O1A
4O1B
4O1C
4O1D
4O28
4WQ6
5KIT
5LX3
5LX5
5NSD
5U2M
5U2N
5UPE
5UPF
5WI0
5WI1
6ATB
6AZJ
6B75
6B76
6E68
6PEB
1GZK
1GZN
1GZO
1MRV
1MRY
1O6K
1O6L
1P6S
2JDO
2JDR
2UW9
2X39
2XH5
3D0E
3E87
3E88
3E8D
Enriched GO Terms of Interacting Partners
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