CHAF1A and DBF4

Data Source:
HPRD (two hybrid, in vivo)

		CHAF1A	DBF4
Description		chromatin assembly factor 1 subunit A	DBF4 zinc finger
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Protein-containing Complex CAF-1 Complex	Nucleus Nucleoplasm Nuclear Body Dbf4-dependent Protein Kinase Complex
	Molecular Function	Chromatin Binding Protein Binding Identical Protein Binding Unfolded Protein Binding Chromo Shadow Domain Binding	Nucleic Acid Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	DNA Replication DNA Repair Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly Cell Cycle Chromatin Assembly	G1/S Transition Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Phase Transition
Pathways			Activation of ATR in response to replication stress Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252 28957414)	Metabolite levels ( 23823483)
Interacting Genes		47 interacting genes: ANP32A ANP32B ASF1A ASF1B BLM CBX1 CBX5 CDC7 CDK2 CHAF1B CREBBP DBF4 DDX41 H3-4 H3C6 HMGB2 LZTR1 MBD1 MEI4 MSH6 NOTO PABPC1 PAX6 PCBD2 PCNA POU6F2 RBFOX2 REL SERTAD1 SET SPOP STAT5B SUMO1 SUMO2 SUMO3 TCERG1 TCF4 TRIB3 TRIM28 XRCC5 XRCC6 YWHAB YWHAE YWHAG YWHAQ ZNF408 ZNF620	18 interacting genes: BRCA1 CDC7 CDK2 CHAF1A CHEK2 LSM8 MCM2 MCM3 MCM4 MCM6 MCM7 MCMBP MEN1 ORC1 ORC2 ORC3 ORC5 ORC6
Entrez ID		10036	10926
HPRD ID		03148	10371
Ensembl ID		ENSG00000167670	ENSG00000006634
Uniprot IDs		Q13111	B4DXK0 B7Z8C6 Q9UBU7
PDB IDs			4F99 4F9A 4F9B 4F9C 6YA6 6YA7 6YA8
Enriched GO Terms of Interacting Partners?
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