KCNE3 and POLA2

Data Source:
BioGRID (two hybrid)

		KCNE3	POLA2
Description		potassium voltage-gated channel subfamily E regulatory subunit 3	DNA polymerase alpha 2, accessory subunit
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Dendrite Vesicle Neuronal Cell Body Membrane Perikaryon Membrane Raft	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol
	Molecular Function	Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Molecular_function DNA Binding Protein Binding
	Biological Process	Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Voltage-gated Potassium Channel Activity Negative Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication
Pathways		Phase 3 - rapid repolarisation Phase 2 - plateau phase	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs		Enflurane Promethazine Miconazole	Dacarbazine
Diseases		Brugada syndrome (BRS)
GWAS		Corneal astigmatism ( 22144915) Neuritic plaque ( 31497858)	Acne (severe) ( 24927181) Serum uric acid levels ( 32514006)
Interacting Genes		10 interacting genes: C11orf68 EEF1A1 GAPDH GOLM1 KIF5A LRIF1 POLA2 QARS1 RASSF1 SLC44A1	33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1
Entrez ID		10008	23649
HPRD ID		07256	10160
Ensembl ID		ENSG00000175538	ENSG00000014138
Uniprot IDs		Q6IAE6 Q9Y6H6	Q14181
PDB IDs		2NDJ 6V00 6V01	2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
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