ACOT8 and P4HA3

Data Source:
BioGRID (two hybrid)

		ACOT8	P4HA3
Description		acyl-CoA thioesterase 8	prolyl 4-hydroxylase subunit alpha 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Peroxisomal Matrix Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	Acetyl-CoA Hydrolase Activity Succinyl-CoA Hydrolase Activity Protein Binding CoA Hydrolase Activity Palmitoyl-CoA Hydrolase Activity Choloyl-CoA Hydrolase Activity Glutaryl-CoA Hydrolase Activity Acetoacetyl-CoA Hydrolase Activity Acyl-CoA Hydrolase Activity Hydroxymethylglutaryl-CoA Hydrolase Activity Carboxylic Ester Hydrolase Activity Medium-chain Acyl-CoA Hydrolase Activity Long-chain Acyl-CoA Hydrolase Activity Myristoyl-CoA Hydrolase Activity	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen L-ascorbic Acid Binding
	Biological Process	Protein Targeting To Peroxisome Acyl-CoA Metabolic Process Bile Acid Biosynthetic Process Fatty Acid Catabolic Process Viral Process Peroxisome Fission Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Dicarboxylic Acid Catabolic Process Negative Regulation Of CD4 Production	Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol alpha-linolenic acid (ALA) metabolism Beta-oxidation of pristanoyl-CoA Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import	Collagen biosynthesis and modifying enzymes
Drugs
Diseases
GWAS			Hippocampal atrophy ( 25625606)
Interacting Genes		5 interacting genes: FBXO7 P4HA3 PEX5 PRDM16 REL	50 interacting genes: ACOT8 ADRA2C ANAPC11 ATN1 B9D2 BAG4 BLOC1S2 C1orf112 C1QTNF2 CERCAM CKMT2 CLPP CT55 CTAG1A CTAG1B CTNNBIP1 DTNBP1 FAM136A GGA3 GPSM3 HGS KRTAP19-5 KRTAP6-1 KRTAP8-1 LRP2BP MAGEA2 MAGEA2B MAGEC2 MCCD1 MEOX2 MSRA NDN NICN1 NUTM1 OIP5 P4HB PROP1 PSMB4 RBFOX1 RUSC1 SCARA5 SERTAD1 SERTAD3 STMN3 TLE5 TOX2 VPS37C WDR62 ZBTB7B ZC3H12A
Entrez ID		10005	283208
HPRD ID		06998	16413
Ensembl ID		ENSG00000101473	ENSG00000149380
Uniprot IDs		A0A494C0N6 O14734	Q7Z4N8
PDB IDs
Enriched GO Terms of Interacting Partners?
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