LRRC8B

Description		leucine rich repeat containing 8 VRAC subunit B
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Ion Channel Complex
	Molecular Function	Volume-sensitive Anion Channel Activity Protein Binding
	Biological Process	Inorganic Anion Transport Transmembrane Transport Anion Transmembrane Transport
Pathways		Miscellaneous transport and binding events
Drugs
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494)
Novel Interacting Genes		3 novel interacting genes: GBP2 GBP3 LRRC8D
Interacting Genes
Entrez ID		23507
HPRD ID		18145
Ensembl ID		ENSG00000197147
Uniprot IDs		A0A384N5V6 Q6P9F7
PDB IDs
Enriched GO Terms of Interacting Partners?
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