LRRC8B and GBP2

Data Source:
HPRD (in vivo, in vitro)

		LRRC8B	GBP2
Description		leucine rich repeat containing 8 VRAC subunit B	guanylate binding protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Ion Channel Complex	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Volume-sensitive Anion Channel Activity Protein Binding	GTPase Activity Protein Binding GTP Binding Protein Homodimerization Activity
	Biological Process	Inorganic Anion Transport Transmembrane Transport Anion Transmembrane Transport	Immune Response Protein Localization To Nucleus Defense Response To Protozoan Defense Response To Gram-positive Bacterium Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor
Pathways		Miscellaneous transport and binding events	Interferon gamma signaling Interferon alpha/beta signaling
Drugs
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494)
Interacting Genes			22 interacting genes: ANXA7 BID BNIP3L BTBD2 CSNK2B FBXO7 FXR1 GADD45A GSK3B HSPE1 KLHL20 LSM2 MAGI1 MAPK8IP2 PAFAH1B3 PPP1R8 RPS6KA1 SAT1 SEPHS1 SERPINB9 STK3 TFG
Entrez ID		23507	2634
HPRD ID		18145	02682
Ensembl ID		ENSG00000197147	ENSG00000162645
Uniprot IDs		A0A384N5V6 Q6P9F7	P32456 Q8TCE5
PDB IDs
Enriched GO Terms of Interacting Partners?
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