LRRC8B and GBP3

Data Source:
BioGRID (affinity chromatography technology)

		LRRC8B	GBP3
Description		leucine rich repeat containing 8 VRAC subunit B	guanylate binding protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Ion Channel Complex	Golgi Membrane Cytoplasm Cytosol Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Volume-sensitive Anion Channel Activity Protein Binding	GTPase Activity Protein Binding GTP Binding Protein Homodimerization Activity
	Biological Process	Inorganic Anion Transport Transmembrane Transport Anion Transmembrane Transport	Defense Response To Virus Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor
Pathways		Miscellaneous transport and binding events	Interferon gamma signaling
Drugs
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494)	Carotid intima media thickness ( 26343869)
Interacting Genes			1 interacting genes: MAP4K4
Entrez ID		23507	2635
HPRD ID		18145	02683
Ensembl ID		ENSG00000197147	ENSG00000117226
Uniprot IDs		A0A384N5V6 Q6P9F7	Q9H0R5
PDB IDs
Enriched GO Terms of Interacting Partners?
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