ZDHHC17 - Wiki-CORONA

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
-	leucine carboxyl methyltransferase 1 pseudogene
ABCG4	ATP binding cassette subfamily G member 4	ABC transporters in lipid homeostasis
ACTR1B	actin related protein 1B	MHC class II antigen presentation Neutrophil degranulation
ADD1	adducin 1	Caspase-mediated cleavage of cytoskeletal proteins XBP1(S) activates chaperone genes Miscellaneous transport and binding events
AHDC1	AT-hook DNA binding motif containing 1
AIDA	axin interactor, dorsalization associated
AK3	adenylate kinase 3	Factors involved in megakaryocyte development and platelet production
ALKBH3	alkB homolog 3, alpha-ketoglutaratedependent dioxygenase	ALKBH3 mediated reversal of alkylation damage	Vitamin C
ANKRD50	ankyrin repeat domain 50
ANXA11	annexin A11
APBB1IP	amyloid beta precursor protein binding family B member 1 interacting protein	Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
ARFGAP3	ADP ribosylation factor GTPase activating protein 3	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
ASF1A	anti-silencing function 1A histone chaperone	Formation of Senescence-Associated Heterochromatin Foci (SAHF)
ASIC4	acid sensing ion channel subunit family member 4	Stimuli-sensing channels
BCAS3	BCAS3 microtubule associated cell migration factor
BEX2	brain expressed X-linked 2
BTF3	basic transcription factor 3
C1orf216	chromosome 1 open reading frame 216
C20orf141	chromosome 20 open reading frame 141
CBS	cystathionine beta-synthase	Cysteine formation from homocysteine Cysteine formation from homocysteine Metabolism of ingested SeMet, Sec, MeSec into H2Se	Pyridoxal Phosphate Ademetionine Serine L-Cysteine	Homocystinuria
CCDC120	coiled-coil domain containing 120
CCDC7	coiled-coil domain containing 7
CCNE2	cyclin E2	G0 and Early G1 SCF(Skp2)-mediated degradation of p27/p21 DNA Damage/Telomere Stress Induced Senescence Association of TriC/CCT with target proteins during biosynthesis TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CDK-mediated phosphorylation and removal of Cdc6 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition p53-Dependent G1 DNA Damage Response		Laryngeal cancer Gastric cancer
CDSN	corneodesmosin	Formation of the cornified envelope		Hypotrichosis simplex of scalp
CENPBD1P1	CENPB DNA-binding domains containing 1 pseudogene 1
CHMP1A	charged multivesicular body protein 1A	HCMV Late Events
CIB1	calcium and integrin binding 1		Calcium Citrate Calcium Phosphate
CLRN3	clarin 3
CNDP2	carnosine dipeptidase 2	Glutathione synthesis and recycling
CNKSR1	connector enhancer of kinase suppressor of Ras 1	MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
COG3	component of oligomeric golgi complex 3	COPI-mediated anterograde transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
CSTA	cystatin A	Formation of the cornified envelope
CTCFL	CCCTC-binding factor like
CTHRC1	collagen triple helix repeat containing 1
DALRD3	DALR anticodon binding domain containing 3
DELE1	DAP3 binding cell death enhancer 1
DIXDC1	DIX domain containing 1
DLG4	discs large MAGUK scaffold protein 4	Signaling by ERBB4 Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RHO GTPases activate CIT RAF/MAP kinase cascade LGI-ADAM interactions Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Guanidine Guanosine-5'-Monophosphate
DLK1	delta like non-canonical Notch ligand 1	Activated NOTCH1 Transmits Signal to the Nucleus
DR1	down-regulator of transcription 1	HATs acetylate histones
DTX3	deltex E3 ubiquitin ligase 3
E2F8	E2F transcription factor 8	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
EDRF1	erythroid differentiation regulatory factor 1
EEF1G	eukaryotic translation elongation factor 1 gamma	Eukaryotic Translation Elongation
ERCC6L	ERCC excision repair 6 like, spindle assembly checkpoint helicase	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
EVL	Enah/Vasp-like	Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors RHO GTPases Activate Formins
EXOSC9	exosome component 9	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
EYA3	EYA transcriptional coactivator and phosphatase 3	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
FAM122C	family with sequence similarity 122C
FAM207A	family with sequence similarity 207 member A
FAM9A	family with sequence similarity 9 member A
FBH1	F-box DNA helicase 1
FOXD4L6	forkhead box D4 like 6
FTL	ferritin light chain	Scavenging by Class A Receptors Golgi Associated Vesicle Biogenesis Neutrophil degranulation Iron uptake and transport	Iron Dextran Protoporphyrin Sodium ferric gluconate complex	Neurodegeneration with brain iron accumulation (NBIA); Hallervorden-Spatz syndrome; Neuroferritinopathy; Aceruloplasminemia
FUT2	fucosyltransferase 2	ABO blood group biosynthesis Lewis blood group biosynthesis
FUT9	fucosyltransferase 9	Lewis blood group biosynthesis
GABPB1	GA binding protein transcription factor subunit beta 1
GABPB2	GA binding protein transcription factor subunit beta 2
GATA1	GATA binding protein 1	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production		Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM) Congenital dyserythropoietic anemias (CDAs)
GOLPH3L	golgi phosphoprotein 3 like
GPR135	G protein-coupled receptor 135
GRB10	growth factor receptor bound protein 10	Signaling by SCF-KIT IRS activation Signal attenuation Insulin receptor signalling cascade RET signaling Response of EIF2AK1 (HRI) to heme deficiency
GUSBP3	GUSB pseudogene 3
H2AP	H2A.P histone
H2BC9	H2B clustered histone 9	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Amyloid fiber formation
H3C10	H3 clustered histone 10	Interleukin-7 signaling Interleukin-7 signaling Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines Chromatin modifying enzymes SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Amyloid fiber formation Factors involved in megakaryocyte development and platelet production
HBG1	hemoglobin subunit gamma 1	Factors involved in megakaryocyte development and platelet production
HECTD3	HECT domain E3 ubiquitin protein ligase 3	Antigen processing: Ubiquitination & Proteasome degradation
HLA-A	major histocompatibility complex, class I, A	ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Interferon gamma signaling E3 ubiquitin ligases ubiquitinate target proteins Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Coccidioides immitis spherule
HLA-DRB1	major histocompatibility complex, class II, DR beta 1	Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling		Type I diabetes mellitus Dilated cardiomyopathy (DCM) Tuberculosis Asthma Graves' disease Systemic lupus erythematosus Hashimoto's thyroiditis
HMBS	hydroxymethylbilane synthase	Heme biosynthesis		Hepatic porphyria, including: Porphyria Cutanea Tarda (PCT); VHepatoerythropoietic porphyria; Acute Intermittent Porphyria (AIP); Variegate porphyria (VP); ALA-dehydratase deficiency porphyria (ALADP); Hereditary Coproporphyria (HCP)
HOXA3	homeobox A3	Activation of anterior HOX genes in hindbrain development during early embryogenesis
HS1BP3	HCLS1 binding protein 3
HTT	huntingtin	Regulation of MECP2 expression and activity	Copper	Huntington's disease (HD)
IFT20	intraflagellar transport 20	Intraflagellar transport Intraflagellar transport
IFT57	intraflagellar transport 57	Hedgehog 'off' state Intraflagellar transport Intraflagellar transport
INPP5D	inositol polyphosphate-5-phosphatase D	Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Downstream TCR signaling PECAM1 interactions Interleukin receptor SHC signaling
JMJD7-PLA2G4B	JMJD7-PLA2G4B readthrough	Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PG Hydrolysis of LPC Synthesis of PA XBP1(S) activates chaperone genes
KHDC4	KH domain containing 4, pre-mRNA splicing factor
KIAA0408	KIAA0408
KNSTRN	kinetochore localized astrin (SPAG5) binding protein
KRAS	KRAS proto-oncogene, GTPase	Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF RUNX3 regulates p14-ARF RAS GTPase cycle mutants Signaling downstream of RAS mutants	[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID FARNESYL DIPHOSPHATE	Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome Pancreatic cancer Gastric cancer Colorectal cancer Non-small cell lung cancer Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS) Oral cancer Acute myeloid leukemia (AML) Endometrial Cancer Multiple myeloma Squamous cell carcinoma Kaposi's sarcoma Cholangiocarcinoma Thyroid cancer Cervical cancer Hepatocellular carcinoma Ovarian cancer Gallbladder cancer
KRT17	keratin 17	Keratinization Formation of the cornified envelope		Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
KRT8P12	keratin 8 pseudogene 12
KRTAP11-1	keratin associated protein 11-1	Keratinization
KRTAP9-2	keratin associated protein 9-2	Keratinization
LCA5L	lebercilin LCA5 like
LGALS9C	galectin 9C
LIN28A	lin-28 homolog A	Transcriptional regulation of pluripotent stem cells
LMAN2L	lectin, mannose binding 2 like	COPII-mediated vesicle transport Cargo concentration in the ER
LNCRI	lncRNA radiation induced regulator of PLK1 and RAD51
LRRC45	leucine rich repeat containing 45
LY6G6C	lymphocyte antigen 6 family member G6C	Post-translational modification: synthesis of GPI-anchored proteins
MANF	mesencephalic astrocyte derived neurotrophic factor	Platelet degranulation
MAP3K19	mitogen-activated protein kinase kinase kinase 19
MIIP	migration and invasion inhibitory protein
MLH3	mutL homolog 3	Meiotic recombination		Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
MRFAP1	Morf4 family associated protein 1
MRFAP1L1	Morf4 family associated protein 1 like 1
MSANTD3	Myb/SANT DNA binding domain containing 3
MSRB2	methionine sulfoxide reductase B2	Protein repair
MYBPHL	myosin binding protein H like
MYOZ2	myozenin 2
NCBP1	nuclear cap binding protein subunit 1	SLBP independent Processing of Histone Pre-mRNAs Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Abortive elongation of HIV-1 transcript in the absence of Tat snRNP Assembly RNA Polymerase II Pre-transcription Events FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Processing of Intronless Pre-mRNAs Signaling by FGFR2 IIIa TM Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
NEBL	nebulette
NFATC2IP	nuclear factor of activated T cells 2 interacting protein
NFYC	nuclear transcription factor Y subunit gamma	PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes
NIFK	nucleolar protein interacting with the FHA domain of MKI67
NPFF	neuropeptide FF-amide peptide precursor	Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
ODF2	outer dense fiber of sperm tails 2	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
OFCC1	orofacial cleft 1 candidate 1
OTUD7B	OTU deubiquitinase 7B	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ovarian tumor domain proteases
OTX2	orthodenticle homeobox 2			Anophthalmia and microphthalmia (A/M) Septo-optic dysplasia
PBRM1	polybromo 1	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
PDE4DIP	phosphodiesterase 4D interacting protein
PDZK1IP1	PDZK1 interacting protein 1
PHF5A	PHD finger protein 5A	mRNA Splicing - Major Pathway
PLEKHB1	pleckstrin homology domain containing B1
PPP1R21	protein phosphatase 1 regulatory subunit 21
PPTC7	protein phosphatase targeting COQ7
PRMT5	protein arginine methyltransferase 5	snRNP Assembly RMTs methylate histone arginines Regulation of TP53 Activity through Methylation
PTMA	prothymosin alpha
QRICH1	glutamine rich 1
RAB39B	RAB39B, member RAS oncogene family	RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
RAD51	RAD51 recombinase	HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Transcriptional Regulation by E2F6 Meiotic recombination	Phosphoaminophosphonic Acid-Adenylate Ester Amuvatinib
RANGRF	RAN guanine nucleotide release factor	Phase 0 - rapid depolarisation
RAP1B	RAP1B, member of RAS oncogene family	Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Signaling downstream of RAS mutants
RBM5	RNA binding motif protein 5	mRNA Splicing - Major Pathway
RCAN3	RCAN family member 3
RIC8A	RIC8 guanine nucleotide exchange factor A
RNF20	ring finger protein 20	E3 ubiquitin ligases ubiquitinate target proteins
RNF38	ring finger protein 38
RSBN1L	round spermatid basic protein 1 like
RUBCNL	rubicon like autophagy enhancer
SCNM1	sodium channel modifier 1
SEMA4G	semaphorin 4G
SF3A3	splicing factor 3a subunit 3	mRNA Splicing - Major Pathway	Phenethyl Isothiocyanate
SHOX2	short stature homeobox 2
SKA3	spindle and kinetochore associated complex subunit 3
SLC1A3	solute carrier family 1 member 3	Astrocytic Glutamate-Glutamine Uptake And Metabolism Glutamate Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides Defective SLC1A3 causes episodic ataxia 6 (EA6)	Glutamic Acid	Episodic ataxias
SLC25A31	solute carrier family 25 member 31
SLC9A9	solute carrier family 9 member A9	Sodium/Proton exchangers Defective SLC9A9 causes autism 16 (AUTS16)
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
SNAP25	synaptosome associated protein 25	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type A (BoNT/A) Toxicity of botulinum toxin type C (BoNT/C) Toxicity of botulinum toxin type E (BoNT/E) Neutrophil degranulation GABA synthesis, release, reuptake and degradation	Botulinum Toxin Type A
SOX14	SRY-box transcription factor 14
SP2	Sp2 transcription factor
SPRED2	sprouty related EVH1 domain containing 2	Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling RAS signaling downstream of NF1 loss-of-function variants
SPRY4	sprouty RTK signaling antagonist 4
SREBF2	sterol regulatory element binding transcription factor 2	Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation EGR2 and SOX10-mediated initiation of Schwann cell myelination
SRSF4	serine and arginine rich splicing factor 4	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination	Artenimol
STK25	serine/threonine kinase 25
STN1	STN1 subunit of CST complex	Telomere C-strand synthesis initiation
SUMF2	sulfatase modifying factor 2	Glycosphingolipid metabolism The activation of arylsulfatases
SYT1	synaptotagmin 1	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Toxicity of botulinum toxin type B (BoNT/B) Toxicity of botulinum toxin type G (BoNT/G) Neurexins and neuroligins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis GABA synthesis, release, reuptake and degradation
TEAD1	TEA domain transcription factor 1	YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination
THAP7	THAP domain containing 7
TIGD1	tigger transposable element derived 1
TMC6	transmembrane channel like 6	Neutrophil degranulation		Epidermodysplasia verruciformis
TMCC1	transmembrane and coiled-coil domain family 1
TMEM115	transmembrane protein 115	COPI-mediated anterograde transport
TMEM186	transmembrane protein 186
TMTC1	transmembrane O-mannosyltransferase targeting cadherins 1
TNFAIP1	TNF alpha induced protein 1
TNFSF10	TNF superfamily member 10	Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited Dimerization of procaspase-8 TRAIL signaling
TOX	thymocyte selection associated high mobility group box
TPGS2	tubulin polyglutamylase complex subunit 2	Carboxyterminal post-translational modifications of tubulin
TTC23	tetratricopeptide repeat domain 23
TTLL7	tubulin tyrosine ligase like 7	Carboxyterminal post-translational modifications of tubulin
TUT7	terminal uridylyl transferase 7	Deadenylation of mRNA
TXNDC12	thioredoxin domain containing 12		Glutathione
TXNDC15	thioredoxin domain containing 15
UBAC1	UBA domain containing 1	Antigen processing: Ubiquitination & Proteasome degradation
UBE2K	ubiquitin conjugating enzyme E2 K	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation
USP18	ubiquitin specific peptidase 18	ISG15 antiviral mechanism Ub-specific processing proteases Regulation of IFNA signaling
USP32	ubiquitin specific peptidase 32
VN1R10P	vomeronasal 1 receptor 10 pseudogene
VSX2	visual system homeobox 2			Anophthalmia and microphthalmia (A/M)
WAC	WW domain containing adaptor with coiled-coil	E3 ubiquitin ligases ubiquitinate target proteins
WDR20	WD repeat domain 20	Ub-specific processing proteases
YIF1A	Yip1 interacting factor homolog A, membrane trafficking protein	XBP1(S) activates chaperone genes
YTHDF3	YTH N6-methyladenosine RNA binding protein 3
ZCCHC17	zinc finger CCHC-type containing 17
ZFC3H1	zinc finger C3H1-type containing
ZFP2	ZFP2 zinc finger protein	Generic Transcription Pathway
ZFP36	ZFP36 ring finger protein	Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
ZFYVE19	zinc finger FYVE-type containing 19
ZNF333	zinc finger protein 333	Generic Transcription Pathway
ZNF341	zinc finger protein 341
ZNF597	zinc finger protein 597	Generic Transcription Pathway
ZNF624	zinc finger protein 624	Generic Transcription Pathway
ZNF667-AS1	ZNF667 antisense RNA 1 (head to head)
ZSCAN9	zinc finger and SCAN domain containing 9

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