PDZD3 - Wiki-CORONA

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
ABCC2	ATP binding cassette subfamily C member 2	Heme degradation ABC-family proteins mediated transport Defective ABCC2 causes Dubin-Johnson syndrome	ATP Sulfinpyrazone	Hyperbilirubinemia; Crigler-Najjar syndrome, type I (CN1); Crigler-Najjar syndrome, type II (CN2); Gilbert Syndrome; Dubin-Johnson syndrome (DJS)
ASAP3	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
CACNA1S	calcium voltage-gated channel subunit alpha1 S	NCAM1 interactions Phase 0 - rapid depolarisation Phase 2 - plateau phase	Isradipine Amlodipine Nimodipine Nisoldipine Spironolactone Cinnarizine Magnesium Sulfate Verapamil Ethanol Felodipine Nitrendipine Nifedipine Mibefradil Dronedarone Clevidipine Nilvadipine Trimebutine Pinaverium Manidipine	Hypokalemic periodic paralysis (HypoPP)
CFTR	CF transmembrane conductance regulator	ABC-family proteins mediated transport RHO GTPases regulate CFTR trafficking Defective CFTR causes cystic fibrosis Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	ATP Bumetanide Glyburide Ibuprofen Colforsin Phosphoaminophosphonic Acid-Adenylate Ester Dexfosfoserine Crofelemer Lonidamine Ivacaftor Dexibuprofen Lumacaftor	Cystic fibrosis (CF) Hereditary pancreatitis; Hereditary chronic pancreatitis Congenital bilateral absence of vas deferens
GUCY2C	guanylate cyclase 2C	Digestion Intestinal infectious diseases	Linaclotide
NLRX1	NLR family member X1	DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling
PTGIR	prostaglandin I2 receptor	Prostanoid ligand receptors Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Treprostinil Iloprost Dinoprost Tromethamine Epoprostenol Beraprost Selexipag
SLC15A1	solute carrier family 15 member 1	Proton/oligopeptide cotransporters	Ampicillin Phenoxymethylpenicillin Cefotaxime Oxacillin Ibuprofen Benzylpenicillin Ceftriaxone Benzoic Acid
SLC15A2	solute carrier family 15 member 2	Proton/oligopeptide cotransporters	Ampicillin Cefotaxime Oxacillin Benzylpenicillin
SLC22A3	solute carrier family 22 member 3	Abacavir transmembrane transport Organic cation transport
SLC22A4	solute carrier family 22 member 4	Organic cation transport	L-Carnitine	Crohn's disease
SLC22A5	solute carrier family 22 member 5	Carnitine metabolism Organic cation transport Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)	L-Carnitine	Crohn's disease Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
SLC22A9	solute carrier family 22 member 9
SLC41A3	solute carrier family 41 member 3
SLCO1A2	solute carrier organic anion transporter family member 1A2	Recycling of bile acids and salts Transport of organic anions	Rifampicin
SLCO1C1	solute carrier organic anion transporter family member 1C1	Transport of organic anions
SLCO3A1	solute carrier organic anion transporter family member 3A1
SPRYD7	SPRY domain containing 7

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