NR1D2 and KRTAP4-2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		NR1D2	KRTAP4-2
Description		nuclear receptor subfamily 1 group D member 2	keratin associated protein 4-2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex	Cytosol Keratin Filament
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Nuclear Receptor Transcription Coactivator Activity Signaling Receptor Activity Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Multicellular Organism Development Hormone-mediated Signaling Pathway Regulation Of Lipid Metabolic Process Cell Differentiation Intracellular Receptor Signaling Pathway Response To Lipid Regulation Of Circadian Rhythm Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Circadian Behavior Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Lipid Homeostasis Energy Homeostasis Regulation Of Skeletal Muscle Cell Differentiation	Keratinization
Pathways		Nuclear Receptor transcription pathway	Keratinization
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Asthma ( 29273806) Cognitive ability ( 29186694) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Metabolite levels ( 23823483)
Interacting Genes		24 interacting genes: CRY1 CSNK1E CSNK2A2 CUL1 DELEC1 GTF2B HDAC1 KRT40 KRTAP10-9 KRTAP4-2 MID2 NCOA5 NCOR1 NOTCH2NLA NR1D1 PRMT6 RBPMS RGN RORC SIN3B TAF6 TAF9 TRIM27 UBE2I	75 interacting genes: ADAMTSL4 ALDH3B1 AMOTL2 AQP1 ATG9A AXIN1 BYSL CHIC2 CHRD CRCT1 CREB5 DLGAP2 DOCK2 FAM74A4 GLRX3 GNMT HOXA1 HPCAL1 HSD3B7 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP26-1 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LASP1 LCE1B LCE2A LCE3C LCE3E LCE4A LNX1 MEOX2 NECTIN3 NLK NOTCH2NLA NR1D2 NTAQ1 NUFIP2 OTX1 PDE9A PGLS PIN1 PLSCR1 POM121L8P PRKAB2 PRKAG1 PSMA6 RASSF5 RGS20 SDC3 SHFL SLC23A1 SLC25A10 SPATA24 SPATA3 SPRY1 TCEANC TINAGL1 TRIM42 TXNDC5 TYRO3 ZBTB24 ZNF124 ZNF20 ZNF417 ZNF559 ZNF581 ZNF688
Entrez ID		9975	85291
HPRD ID		03809	13944
Ensembl ID		ENSG00000174738	ENSG00000244537
Uniprot IDs		B4DXD3 F1D8P2 Q14995	Q9BYR5
PDB IDs		2V0V 2V7C 3CQV 4N73
Enriched GO Terms of Interacting Partners?
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