NUP153 and RAN

Number of citations of the paper that reports this interaction (PubMedID 10202161)
77

Data Source:
HPRD (in vitro)

		NUP153	RAN
Description		nucleoporin 153	RAN, member RAS oncogene family
Image
GO Annotations	Cellular Component	Nuclear Pore Nucleoplasm Nucleolus Cytosol Membrane Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Host Cell Nuclear Pore Central Transport Channel Nuclear Pore Nuclear Basket	Chromatin Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Nucleolus Cytoplasm Centriole Cytosol Membrane Midbody Protein-containing Complex Melanosome RNA Nuclear Export Complex Host Cell Recycling Endosome Extracellular Exosome Flemming Body
	Molecular Function	DNA Binding Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore Identical Protein Binding Protein Membrane Anchor Metal Ion Binding	Magnesium Ion Binding Chromatin Binding RNA Binding GTPase Activity Nuclear Export Signal Receptor Activity Protein Binding GTP Binding GDP Binding Cadherin Binding Protein Heterodimerization Activity Androgen Receptor Binding Pre-miRNA Binding
	Biological Process	Regulation Of Glycolytic Process RNA Export From Nucleus MRNA Export From Nucleus TRNA Export From Nucleus Protein Import Into Nucleus Viral Process Protein Sumoylation Viral Transcription Viral Entry Into Host Cell Negative Regulation Of RNA Export From Nucleus Nuclear Pore Complex Assembly Regulation Of Gene Silencing By MiRNA Viral Penetration Into Host Nucleus Intracellular Transport Of Virus Regulation Of Cellular Response To Heat	Ribosomal Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Mitotic Sister Chromatid Segregation Mitotic Cell Cycle DNA Metabolic Process TRNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Mitotic Spindle Organization MiRNA Metabolic Process Viral Process Androgen Receptor Signaling Pathway Positive Regulation Of Protein Binding Pre-miRNA Export From Nucleus Positive Regulation Of Protein Import Into Nucleus Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription, DNA-templated GTP Metabolic Process Cell Division SnRNA Import Into Nucleus Intracellular Transport Of Virus Protein Localization To Nucleolus
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events	Rev-mediated nuclear export of HIV RNA Regulation of cholesterol biosynthesis by SREBP (SREBF) NEP/NS2 Interacts with the Cellular Export Machinery Nuclear import of Rev protein MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs tRNA processing in the nucleus Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation
Drugs			Guanosine-5'-Diphosphate
Diseases
GWAS		Height ( 18391951) Obesity-related traits ( 23251661)
Interacting Genes		26 interacting genes: APC BRCA1 CLK1 DYNLT1 IPO5 KPNA2 KPNB1 MAPK1 MAPK14 MAPK3 MRPS5 NUP62 NUTF2 NXF1 NXF2 RAN SENP2 SMAD2 SMAD3 TNPO1 TPR TRN-GTT2-7 XPO1 XPO5 XPO7 XPOT	57 interacting genes: ABL1 ADRB2 AR ASAP2 BCAR1 BIRC5 BMPR1B CEP126 CSE1L EP300 GADD45G GIT1 IPO11 IPO13 IPO5 IPO7 KPNA2 KPNB1 MBP MSL1 NEK9 NR3C1 NSMF NUP153 NUP50 NUPR1 NUTF2 NXF1 NXT1 PAK4 PARP10 PTMA RANBP1 RANBP10 RANBP2 RANBP3 RANBP9 RANGAP1 RANGRF RCC1 RGPD5 RPL7 SMAD1 SMAD2 SMARCB1 SMURF2 SNUPN SPAG8 SSRP1 TGFBR1 TNPO1 TNPO2 XPO1 XPO4 XPO5 XPO7 XPOT
Entrez ID		9972	5901
HPRD ID		04899	03109
Ensembl ID		ENSG00000124789	ENSG00000132341
Uniprot IDs		P49790	B4DV51 P62826
PDB IDs		2EBQ 2EBR 2EBV 2GQE 4U0C 4U0D 5TSV 5TSX 6AYA	1I2M 1IBR 1K5D 1K5G 1QBK 1RRP 2MMC 2MMG 2N1B 3CH5 3EA5 3GJ0 3GJ3 3GJ4 3GJ5 3GJ6 3GJ7 3GJ8 3GJX 3NBY 3NBZ 3NC0 3NC1 3ZJY 4C0Q 4GMX 4GPT 4HAT 4HAU 4HAV 4HAW 4HAX 4HAY 4HAZ 4HB0 4HB2 4HB3 4HB4 4OL0 4WVF 5CIQ 5CIT 5CIW 5CJ2 5CLL 5CLQ 5DH9 5DHA 5DHF 5DI9 5DIF 5DIS 5DLQ 5FYQ 5JLJ 5UWH 5UWI 5UWJ 5UWO 5UWP 5UWQ 5UWR 5UWS 5UWT 5UWU 5UWW 5YRO 5YST 5YSU 5YTB 5ZPU 6A38 6A3A 6A3B 6A3C 6A3E 6CIT 6Q82 6Q84
Enriched GO Terms of Interacting Partners?
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