HELZ and SMYD3

Number of citations of the paper that reports this interaction (PubMedID 15235609)
219

Data Source:
HPRD (in vivo, in vitro)

		HELZ	SMYD3
Description		helicase with zinc finger	SET and MYND domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Membrane P Granule	Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Binding Helicase Activity Protein Binding ATP Binding Metal Ion Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Complex Binding RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Histone-lysine N-methyltransferase Activity Metal Ion Binding
	Biological Process	Posttranscriptional Gene Silencing By RNA	Nucleosome Assembly Negative Regulation Of Protein Kinase Activity Myotube Cell Development Positive Regulation Of Peptidyl-serine Phosphorylation Histone Lysine Methylation Establishment Of Protein Localization Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Dexamethasone Stimulus
Pathways			PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Putamen volume ( 29147026) Visceral fat ( 30942860)	Bipolar disorder ( 31043756) Blood metabolite levels ( 26401656) Coffee consumption ( 31046077) Fractional exhaled nitric oxide (childhood) ( 24315451) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Response to serotonin reuptake inhibitors in non-psychotic unipolar depression ( 26348319) Systemic lupus erythematosus ( 29848360) Upper eyelid sagging severity ( 24869959)
Interacting Genes		4 interacting genes: GRB2 SH3YL1 SMYD3 STAT5A	17 interacting genes: APP CAMK2B CYP39A1 EED EZH2 H3-4 H3-5 HELZ HSP90AA1 NDUFAB1 NFYB PBX2 POLR2K SCCPDH TRIT1 VANGL1 ZNF557
Entrez ID		9931	64754
HPRD ID		10452	12297
Ensembl ID		ENSG00000198265	ENSG00000185420
Uniprot IDs		A0A024R8K8 A0A2P0H7U5 B7ZLW2 P42694	B3KN46 Q9H7B4
PDB IDs			3MEK 3OXF 3OXG 3OXL 3PDN 3QWP 3RU0 5CCL 5CCM 5EX0 5EX3 5HI7 5HQ8 5V37 5XXD 5XXG 5XXJ 5YJO 6IJL
Enriched GO Terms of Interacting Partners?
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