FCHSD2 and HTRA1

Number of citations of the paper that reports this interaction (PubMedID 15101818)
29

Data Source:
HPRD (two hybrid)

		FCHSD2	HTRA1
Description		FCH and double SH3 domains 2	HtrA serine peptidase 1
Image
GO Annotations	Cellular Component	Plasma Membrane Clathrin-coated Pit Cell Junction Neuromuscular Junction Recycling Endosome Stereocilium Shaft	Extracellular Region Extracellular Space Cytosol Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding	Serine-type Endopeptidase Activity Protein Binding Insulin-like Growth Factor Binding Serine-type Peptidase Activity Identical Protein Binding
	Biological Process	Neuromuscular Synaptic Transmission Protein Transport Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Multi-organism Membrane Organization Clathrin-dependent Endocytosis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Placenta Development Proteolysis Extracellular Matrix Disassembly Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Defense Response To Virus Chorionic Trophoblast Cell Differentiation Dentinogenesis
Pathways			Degradation of the extracellular matrix
Drugs
Diseases			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		Albumin-globulin ratio ( 29403010) Crohn's disease ( 23850713 23266558) Endometrial cancer (endometrioid histology) ( 30093612) Health literacy ( 31250787) Serum total protein level ( 29403010) Systemic lupus erythematosus ( 26663301)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 22694956 23326517 23455636 23536807 20861866 21665990) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (CNV vs. GA) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (geographic atrophy) ( 22705344) Age-related macular degeneration (wet) ( 17053108) Coronary artery disease ( 29212778) Disease progression in age-related macular degeneration ( 29346644) Disease progression to choroidal neovascularization form in age-related macular degeneration ( 29346644) Disease progression to geographic atrophy form in age-related macular degeneration ( 29346644) Diverticular disease ( 30177863) Exudative age-related macular degeneration ( 25629512) Laterality in neovascular age-related macular degeneration ( 28775256) Lung function (FEV1/FVC) ( 30061609 30804560) Migraine ( 27322543) Neovascular age-related macular degeneration ( 28703135) Stroke ( 29531354) Systolic blood pressure ( 30224653 30578418)
Interacting Genes		26 interacting genes: ABCF3 C2orf73 C9orf78 CASK CCDC158 CCDC85B CCT2 CFAP36 CHKA DAPP1 FAM9B HGS HSP90AB1 HSPA5 HTRA1 ITSN1 ITSN2 KIFC3 MSL1 MTUS2 PDE4DIP SH3BGR SRP72 VCPIP1 WAS WASL	21 interacting genes: APOE BMP4 CAST CDYL COL1A1 COL2A1 COL3A1 COX5A CSNK2B FAM107A FCHSD2 GDF5 GOLGA2 IMPDH1 LRP10 MAPT NOS3 PARD6B RPS6KA1 TENT5A XIAP
Entrez ID		9873	5654
HPRD ID		13321	03725
Ensembl ID		ENSG00000137478	ENSG00000166033
Uniprot IDs		O94868	Q92743
PDB IDs		2DL5 2DL7 6GBU	2JOA 2YTW 3NUM 3NWU 3NZI 3TJN 3TJO 3TJQ
Enriched GO Terms of Interacting Partners?
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