ZEB2 and CBX4

Number of citations of the paper that reports this interaction (PubMedID 16061479)
53

Data Source:
BioGRID (pull down, affinity chromatography technology, enzymatic study)

		ZEB2	CBX4
Description		zinc finger E-box binding homeobox 2	chromobox 4
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytosol	Nucleus Nucleoplasm Nuclear Body Nuclear Speck PcG Protein Complex PRC1 Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Phosphatase Regulator Activity Sequence-specific DNA Binding Metal Ion Binding R-SMAD Binding	Chromatin Binding Transcription Corepressor Activity Single-stranded RNA Binding Protein Binding SUMO Transferase Activity Enzyme Binding SUMO Binding Methylated Histone Binding Transcription Regulatory Region DNA Binding Phosphoprotein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Somitogenesis Neural Tube Closure Nervous System Development Corpus Callosum Morphogenesis Hippocampus Development Cell Proliferation In Forebrain Corticospinal Tract Morphogenesis Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Melanocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Melanin Biosynthetic Process Developmental Pigmentation Collateral Sprouting Positive Regulation Of Axonogenesis Mammillary Axonal Complex Development Melanocyte Migration Positive Regulation Of Lens Fiber Cell Differentiation Regulation Of Melanosome Organization	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Protein Sumoylation Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated
Pathways			Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases		Mowat-Wilson syndrome
GWAS		Adventurousness ( 30643258) Childhood absence epilepsy ( 30531953) Chin dimples ( 27182965) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Corneal astigmatism ( 30306274) Coronary artery disease ( 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 30224653) General risk tolerance (MTAG) ( 30643258) Generalized epilepsy ( 22949513) Hand grip strength ( 29691431) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010) Medication use (diuretics) ( 31015401) Myocardial infarction ( 26343387) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965 30899065) Red blood cell count ( 29403010) Renal cell carcinoma ( 23184150 25826619) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 29483656 23974872) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284)
Interacting Genes		11 interacting genes: APP CBX4 COPS6 CTBP1 CTBP2 SMAD1 SMAD2 SMAD3 SMAD5 SMAD9 UBE2I	21 interacting genes: CBS CREBBP CSNK2B CTBP1 CTBP2 FHL1 H3-4 KMT2A LNX2 MBD1 MED9 MX1 RB1 RING1 RNF2 SATB1 SKIL SPOP SUV39H1 UBE2I ZEB2
Entrez ID		9839	8535
HPRD ID		05780	04357
Ensembl ID		ENSG00000169554	ENSG00000141582
Uniprot IDs		O60315	A0A0S2Z5B2 O00257
PDB IDs		2DA7	2K28 3I8Z 5EPL
Enriched GO Terms of Interacting Partners?
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