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CDK1 and DNM2
Number of citations of the paper that reports this interaction (PubMedID
7590285
)
12
Data Source:
HPRD
(in vivo, in vitro)
CDK1
DNM2
Description
cyclin dependent kinase 1
dynamin 2
Image
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nuclear Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Endoplasmic Reticulum Membrane
Centrosome
Cytosol
Spindle Microtubule
Membrane
Midbody
Extracellular Exosome
Mitotic Spindle
Cyclin B1-CDK1 Complex
Golgi Membrane
Phagocytic Cup
Photoreceptor Inner Segment
Cell
Nucleus
Cytoplasm
Endosome
Golgi Apparatus
Trans-Golgi Network
Centrosome
Cytosol
Microtubule
Plasma Membrane
Clathrin-coated Pit
Focal Adhesion
Postsynaptic Density
Microtubule Cytoskeleton
Membrane
Lamellipodium
Axon
Growth Cone
Midbody
Endocytic Vesicle Membrane
Phagocytic Vesicle Membrane
Cytoplasmic Vesicle
Mitochondrial Membrane
Ruffle Membrane
Protein-containing Complex
Dendritic Spine
Dendritic Spine Head
Synapse
Postsynaptic Membrane
Clathrin-coated Endocytic Vesicle
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Presynapse
Postsynaptic Endocytic Zone Membrane
Glutamatergic Synapse
Postsynaptic Density, Intracellular Component
Molecular Function
Virus Receptor Activity
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Cyclin Binding
Hsp70 Protein Binding
Histone Kinase Activity
Cyclin-dependent Protein Kinase Activity
GTPase Activity
Protein Binding
GTP Binding
Microtubule Binding
SH3 Domain Binding
Enzyme Binding
Protein Kinase Binding
D2 Dopamine Receptor Binding
Phosphatidylinositol 3-kinase Regulatory Subunit Binding
Protein-containing Complex Binding
WW Domain Binding
Nitric-oxide Synthase Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Activation Of MAPK Activity
Microtubule Cytoskeleton Organization
DNA Replication
DNA Repair
Transcription Initiation From RNA Polymerase II Promoter
Protein Phosphorylation
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Mitotic Nuclear Envelope Disassembly
Mitotic G2 DNA Damage Checkpoint
Centrosome Cycle
Pronuclear Fusion
Cell Aging
Cell Proliferation
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Schwann Cell Differentiation
Response To Organic Cyclic Compound
Response To Amine
Response To Activity
Cell Migration
Histone Phosphorylation
Protein Deubiquitination
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Chromosome Condensation
Epithelial Cell Differentiation
Animal Organ Regeneration
Anaphase-promoting Complex-dependent Catabolic Process
Protein Localization To Kinetochore
Positive Regulation Of Protein Import Into Nucleus
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Response To Ethanol
Positive Regulation Of DNA Replication
Regulation Of Embryonic Development
Response To Cadmium Ion
Response To Copper Ion
Viral Entry Into Host Cell
Rhythmic Process
Response To Axon Injury
Cell Division
Ventricular Cardiac Muscle Cell Development
Positive Regulation Of Cardiac Muscle Cell Proliferation
Protein-containing Complex Assembly
Cellular Response To Hydrogen Peroxide
Golgi Disassembly
Ciliary Basal Body-plasma Membrane Docking
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
G2/M Transition Of Mitotic Cell Cycle
Mitochondrial Fission
G Protein-coupled Receptor Internalization
Ventricular Septum Development
Regulation Of Transcription, DNA-templated
Golgi To Plasma Membrane Transport
Endocytosis
Receptor-mediated Endocytosis
Phagocytosis
Signal Transduction
Spermatogenesis
Response To Light Stimulus
Positive Regulation Of Lamellipodium Assembly
Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Axon Extension
Receptor Internalization
Transferrin Transport
Regulation Of Rac Protein Signal Transduction
Aorta Development
Response To Cocaine
Positive Regulation Of Apoptotic Process
Macropinocytosis
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Organelle Fission
Synaptic Vesicle Transport
Neuron Projection Morphogenesis
Positive Regulation Of Phagocytosis
Regulation Of Synapse Structure Or Activity
Regulation Of Nitric-oxide Synthase Activity
Coronary Vasculature Development
Membrane Organization
Membrane Fusion
Cellular Response To Carbon Monoxide
Cellular Response To X-ray
Cellular Response To Nitric Oxide
Postsynaptic Neurotransmitter Receptor Internalization
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Negative Regulation Of Non-motile Cilium Assembly
Cellular Response To Dopamine
Regulation Of Golgi Organization
Positive Regulation Of Sodium:potassium-exchanging ATPase Activity
Negative Regulation Of Membrane Tubulation
Positive Regulation Of Clathrin-dependent Endocytosis
Pathways
MAPK3 (ERK1) activation
E2F-enabled inhibition of pre-replication complex formation
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Golgi Cisternae Pericentriolar Stack Reorganization
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
APC/C:Cdc20 mediated degradation of Cyclin B
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
MASTL Facilitates Mitotic Progression
Resolution of Sister Chromatid Cohesion
Condensation of Prometaphase Chromosomes
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Initiation of Nuclear Envelope (NE) Reformation
Nuclear Pore Complex (NPC) Disassembly
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Depolymerisation of the Nuclear Lamina
Anchoring of the basal body to the plasma membrane
MAPK6/MAPK4 signaling
Ovarian tumor domain proteases
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Degradation
Mitotic Prophase
G1/S-Specific Transcription
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Transcriptional regulation by RUNX2
Toll Like Receptor 4 (TLR4) Cascade
Retrograde neurotrophin signalling
Gap junction degradation
Formation of annular gap junctions
NOSTRIN mediated eNOS trafficking
MHC class II antigen presentation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Recycling pathway of L1
Clathrin-mediated endocytosis
NGF-stimulated transcription
Drugs
Indirubin-3'-Monoxime
Olomoucine
Hymenialdisine
SU9516
Alvocidib
Alsterpaullone
AT7519
Diseases
Centronuclear myopathy
Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS
Cocaine dependence (
23958962
)
Voxel-wise structural brain imaging measurements in Alzheimer’s disease (
31095298
)
Bipolar disorder (
31043756
)
Height (
25429064
)
LDL cholesterol (
21347282
)
Interacting Genes
184 interacting genes:
ABL1
AMPH
APLP2
AR
ARID4A
BARD1
BCL2
BIRC5
BIRC6
BRCA1
BRCA2
BTRC
BUB1
CALD1
CCNA1
CCNA2
CCNB1
CCNB1IP1
CCNB2
CCNE1
CCP110
CD8A
CDC20
CDC25A
CDC25B
CDC25C
CDC6
CDCA2
CDCA5
CDK7
CDKN1A
CDKN3
CDT1
CEP55
CEP63
CHAF1B
CIITA
CKS2
CNOT7
CREM
CSN2
CSNK2A1
CSNK2B
CUX1
CXCR1
DAB2
DCTN6
DNM2
DTL
DUT
E2F1
ECT2
EEF1D
EEF2K
EGFR
EP300
EPN1
ERCC2
FANCA
FANCC
FANCG
FBXO5
FEN1
FOXM1
FYN
GADD45A
GADD45B
GADD45G
GATA2
GBF1
GFAP
GOLGA2
GORASP1
H1-0
H1-1
H1-3
H1-5
H2AC4
H2BC3
H4C1
HMGA1
HMGA2
HMGB1
HSPA2
HTRA2
IL16
IL3RA
ITGB3
ITPR1
JAK3
KAT5
KHDRBS1
KIF11
KIF20B
KIF26B
KMT2E
KRT18
LATS1
LMNA
LMNB1
LYN
LZTS1
MAP4
MAPT
MARCKS
MBP
MCM4
MDM4
MEF2C
MKI67
MLKL
MNDA
MYC
MYT1
NCAPD2
NCAPG
NCAPH
NCL
NDE1
NES
NPM1
NSFL1C
NUP210
PAK6
PBK
PCNA
PIN1
PITPNM1
PKMYT1
PLEC
PML
POLA1
PPP2R1A
PPP2R1B
PPP2R2B
PRC1
PTCH1
PTMA
PTPN1
PTPN2
PTPN6
PTTG1
RAB4A
RAB5B
RACGAP1
RAP1GAP
RB1
RCC1
RELB
REPS2
RGCC
RPA2
RPS6KB1
RRM2
RUNX1
RUNX2
SFN
SP1
SPAG5
SQSTM1
SSBP1
STK3
STMN1
STMN2
TFDP1
TGFBR2
TK1
TLE1
TNNC1
TOP2A
TP53
TP53BP1
TP73
TSC1
TSPYL2
UBA1
UBE2A
UBE3A
UHRF2
USP16
VIM
WEE1
XIAP
ZBTB16
57 interacting genes:
AMPH
AOC1
AP2A1
APP
ATF7IP
ATXN3
BIN1
CCDC90B
CCR5
CCT7
CDK1
CTTN
DDX39B
DNM1
DNMT1
DYNC1I1
DYNLL1
EIF3L
EPS15
FNBP1L
GDF9
GOLGA2
GRAP2
GRB2
HCK
HMGB1
ITSN1
ITSN2
KDR
MAN1B1
MANEA
MPHOSPH6
MPP6
NTAQ1
PDE6G
PFN1
PPIB
PSTPIP1
PTK2
RHOU
RPS2
RWDD2B
SH3GL2
SH3GLB1
SHANK1
SHANK2
SNX9
SPRY2
SRC
TIAM2
TRIP10
TYK2
VAV1
WBP4
XIAP
ZBTB16
ZFAND6
Entrez ID
983
1785
HPRD ID
00302
03852
Ensembl ID
ENSG00000170312
ENSG00000079805
Uniprot IDs
A0A024QZJ8
B7Z3D6
I6L9I5
P06493
P50570
Q8N1K8
PDB IDs
1LC9
4Y72
4YC3
4YC6
5HQ0
5LQF
6GU2
6GU3
6GU4
6GU6
6GU7
2YS1
Enriched GO Terms of Interacting Partners
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