CUL7 and COMMD1

Number of citations of the paper that reports this interaction (PubMedID 21778237)
9

Data Source:
BioGRID (pull down)

		CUL7	COMMD1
Description		cullin 7	copper metabolism domain containing 1
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GO Annotations	Cellular Component	Anaphase-promoting Complex Cytoplasm Golgi Apparatus Centrosome Cytosol Cul7-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm 3M Complex	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Endosome Membrane Cul2-RING Ubiquitin Ligase Complex Recycling Endosome
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Copper Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Sodium Channel Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cytokinesis Vasculogenesis Epithelial To Mesenchymal Transition Placenta Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Golgi Organization Regulation Of Mitotic Nuclear Division Viral Process Protein Ubiquitination IRE1-mediated Unfolded Protein Response Post-translational Protein Modification Positive Regulation Of Dendrite Morphogenesis	Nucleotide-excision Repair Golgi To Plasma Membrane Transport Protein Transport Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Plasma Membrane To Endosome Transport Copper Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface
Pathways		XBP1(S) activates chaperone genes Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Neddylation
Drugs
Diseases		3M syndrome
GWAS			Erectile dysfunction ( 30583798) Height ( 31562340) Iron status biomarkers (total iron binding capacity) ( 28334935) Mean corpuscular volume ( 27863252) Nonalcoholic fatty liver disease ( 31311600)
Interacting Genes		9 interacting genes: COMMD1 FBXW8 MEGF10 MTDH MTNR1A PLXNB3 RBX1 SKP1 UBE2M	29 interacting genes: BAHCC1 BARD1 BRCA1 COMMD10 COMMD2 COMMD3 COMMD4 COMMD5 COMMD6 COMMD7 COMMD8 CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CUL7 ELOC KAT2A LIG4 NFKBIA PRKN RELA SLC12A2 SOCS1 SOD1 SPP1 XIAP
Entrez ID		9820	150684
HPRD ID		09901	06253
Ensembl ID		ENSG00000044090	ENSG00000173163
Uniprot IDs		Q14999	Q8N668
PDB IDs		2JNG	2H2M
Enriched GO Terms of Interacting Partners?
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