TSC22D2 and WNK3

Number of citations of the paper that reports this interaction (PubMedID 27337956)
18

Data Source:
BioGRID (two hybrid)

		TSC22D2	WNK3
Description		TSC22 domain family member 2	WNK lysine deficient protein kinase 3
Image		No pdb structure
GO Annotations	Cellular Component		Cytoplasm Cytosol Adherens Junction Bicellular Tight Junction
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress	Protein Phosphorylation Positive Regulation Of Sodium Ion Transport Negative Regulation Of Sodium Ion Transport Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Ion Transmembrane Transporter Activity Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Protein Autophosphorylation Ion Homeostasis Positive Regulation Of Calcium Ion Transport Protein Localization To Plasma Membrane Negative Regulation Of Pancreatic Juice Secretion Regulation Of Calcium Ion Import Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Potassium Ion Import Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways			Stimuli-sensing channels
Drugs
Diseases
GWAS		Adiponectin levels ( 22479202) Cognitive decline rate in late mild cognitive impairment ( 26252872) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 29891935) Intraocular pressure ( 29235454) Macular thickness ( 30535121) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444) Moyamoya disease ( 29273593) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Type 2 diabetes ( 30054458 30297969) Waist circumference ( 26785701)	Height ( 28552196)
Interacting Genes		43 interacting genes: ANAPC10 ANKRD36 ARID2 ATP1B1 CCDC141 CCDC144A CLIP1 ENOPH1 EPCAM F8 FLNB GPBP1 ITGA2 KIAA0586 LOXHD1 LPL LRRC6 MED13 MPDZ MSH3 MTIF2 NGRN NRBP1 OSBPL1A PRMT3 PSMA7 PSMA8 RBL1 REV1 RNF2 SAP18 SCEL SEC31A SNX3 SPEF2 STK39 TMA7 TTN UFM1 WNK3 ZMYM2 ZNF143 ZNF251	2 interacting genes: KLHL3 TSC22D2
Entrez ID		9819	65267
HPRD ID		11101	02289
Ensembl ID		ENSG00000196428	ENSG00000196632
Uniprot IDs		B4DN36 O75157	Q9BYP7
PDB IDs			5NKP 5O1V 5O21 5O23 5O26 5O2B 5O2C
Enriched GO Terms of Interacting Partners?
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