KEAP1 and AK4

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		KEAP1	AK4
Description		kelch like ECH associated protein 1	adenylate kinase 4
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Actin Filament Inclusion Body Midbody Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite	Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding Transcription Factor Binding Identical Protein Binding Disordered Domain Specific Binding	Adenylate Kinase Activity Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding GTP Binding Nucleoside Triphosphate Adenylate Kinase Activity Nucleoside Monophosphate Kinase Activity
	Biological Process	In Utero Embryonic Development Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Viral Process Protein Ubiquitination Protein Deubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxidative Stress Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA-binding Transcription Factor Activity Post-translational Protein Modification Regulation Of Epidermal Cell Differentiation Cellular Response To Interleukin-4	Liver Development Regulation Of Oxidative Phosphorylation Nucleoside Diphosphate Phosphorylation ADP Biosynthetic Process Brain Development Nucleoside Triphosphate Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Response To Drug AMP Metabolic Process ATP Metabolic Process GTP Metabolic Process Nucleoside Monophosphate Phosphorylation Cellular Response To Hypoxia Regulation Of ATP Biosynthetic Process
Pathways		Ub-specific processing proteases Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Interconversion of nucleotide di- and triphosphates
Drugs		Dimethyl fumarate Artenimol
Diseases
GWAS		Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)	Idiopathic osteonecrosis of the femoral head ( 28000841)
Interacting Genes		49 interacting genes: AK4 AMER1 ATG5 BAD BPTF CAT CCNB1IP1 CDH1 CDK6 CLU CPEB2 CTTN CUL3 EGFR ETF1 FAM117B GLRX5 GYPA HSP90AA1 HSP90AB1 IPO11 IRF1 KLHL3 KPNA6 LSM3 MAD2L1 MAPKBP1 MYO7A NFE2L2 NUDT4 OXR1 PDCD6IP PIDD1 PPP1R13L PRKAG1 PTMA RAF1 RECK RELA SNRPN STK3 STK4 TENT5A TERF1 TRIM15 UBC USP15 WDR83 ZSCAN32	4 interacting genes: APP CEP19 EPHA8 KEAP1
Entrez ID		9817	205
HPRD ID		12079	00048
Ensembl ID		ENSG00000079999	ENSG00000162433
Uniprot IDs		A0A024R7C0 Q14145	F8VS11 P27144
PDB IDs		1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4CXI 4CXJ 4CXT 4IFJ 4IFL 4IFN 4IN4 4IQK 4L7B 4L7C 4L7D 4N1B 4XMB 5DAD 5DAF 5F72 5GIT 5NLB 5WFL 5WFV 5WG1 5WHL 5WHO 5WIY 5X54 6FFM 6FMP 6FMQ 6HWS 6ROG	2AR7 2BBW 3NDP
Enriched GO Terms of Interacting Partners?
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