ARHGAP32 and SHC3

Number of citations of the paper that reports this interaction (PubMedID 12446789)
33

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		ARHGAP32	SHC3
Description		Rho GTPase activating protein 32	SHC adaptor protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Fibrillar Center Nucleoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Cell Cortex Endosome Membrane Postsynaptic Density Actin Cytoskeleton Cell Junction Dendritic Spine	Cellular_component Cytosol Plasma Membrane Synapse
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol Phosphate Binding	Phosphotyrosine Residue Binding Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding
	Biological Process	Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Ras Protein Signal Transduction Axon Guidance Central Nervous System Development Learning Or Memory Synaptic Transmission, Glutamatergic
Pathways		Rho GTPase cycle	Signalling to RAS Signalling to RAS RAF/MAP kinase cascade RET signaling
Drugs
Diseases
GWAS		Intracranial aneurysm ( 30823506) Iris color (L* coordinate) ( 29109912) Macular thickness ( 30535121) Metabolite levels (5-HIAA) ( 23319000)	Logical memory (delayed recall) in Alzheimer's disease dementia ( 29274321) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to statins (LDL cholesterol change) ( 22331829) Superior parietal cortex volume ( 31530798) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		33 interacting genes: ABI2 ATXN1 BCAR1 CAMK2N2 CDC42 CDH1 CDH2 CRK CRKL CTNNB1 DLG4 DZIP3 FYN GAB1 GAB2 GRAP GRB2 GRIN2A GRIN2B LZTS2 MDFI MEGF10 NCK1 NCK2 NPHP1 NTRK1 PIK3R1 PLCG1 RAC1 RHOA SHC3 SRC TLE5	16 interacting genes: ALK APP ARHGAP32 AXL EGFR ERBB2 ERBB3 FLT4 GOLGA2 GRB2 KRT31 KRT40 NTRK1 NTRK2 RET SH3GL3
Entrez ID		9743	53358
HPRD ID		12257	12005
Ensembl ID		ENSG00000134909	ENSG00000148082
Uniprot IDs		A7KAX9 Q86T64	Q92529
PDB IDs		3IUG
Enriched GO Terms of Interacting Partners?
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