HERPUD1 and IMPA2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		HERPUD1	IMPA2
Description		homocysteine inducible ER protein with ubiquitin like domain 1	inositol monophosphatase 2
Image
GO Annotations	Cellular Component	Cell Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Lewy Body Core	Cytoplasm Cytosol
	Molecular Function	Molecular_function Protein Binding Ion Channel Binding Protein Binding, Bridging Involved In Substrate Recognition For Ubiquitination	Protein Binding Inositol Monophosphate 1-phosphatase Activity Protein Homodimerization Activity Metal Ion Binding Inositol Monophosphate 3-phosphatase Activity Inositol Monophosphate 4-phosphatase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Response To Unfolded Protein Protein Ubiquitination Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Regulation Of Protein Ubiquitination Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Inositol Metabolic Process Inositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Signal Transduction Inositol Phosphate Metabolic Process Phosphatidylinositol Phosphorylation Inositol Phosphate Dephosphorylation
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress	Synthesis of IP2, IP, and Ins in the cytosol
Drugs			Lithium
Diseases
GWAS		Cardiovascular risk factors ( 20838585) Coronary artery disease ( 29212778) Diisocyanate-induced asthma ( 25918132) HDL cholesterol ( 20031564 23505323 24886709) HDL Cholesterol in HIV-infection ( 25884002) HDL cholesterol levels ( 26763881 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29403010) LDL cholesterol levels ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low HDL-cholesterol levels ( 31910446) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Total cholesterol levels ( 29403010) Triglyceride levels ( 29403010) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Diabetic peripheral neuropathy in type 2 diabetes ( 31127053) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) Stroke ( 17434096)
Interacting Genes		16 interacting genes: AMFR APP ARHGDIA CD3D CD58 EWSR1 IMPA2 PSEN1 RPA2 SH3RF1 STARD9 TOLLIP UBQLN2 USP7 VCP XRCC6	4 interacting genes: HERPUD1 IMPA1 TNFRSF14 UBA3
Entrez ID		9709	3613
HPRD ID		07456	09329
Ensembl ID		ENSG00000051108	ENSG00000141401
Uniprot IDs		A4UAE9 Q15011 Q53FP9	O14732
PDB IDs		1WGD	2CZH 2CZI 2CZK 2DDK 2FVZ
Enriched GO Terms of Interacting Partners?
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