RIMS2 and RAB27A

Number of citations of the paper that reports this interaction (PubMedID 12578829)
52

Data Source:
HPRD (in vitro, in vivo)

		RIMS2	RAB27A
Description		regulating synaptic membrane exocytosis 2	RAB27A, member RAS oncogene family
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GO Annotations	Cellular Component	Cell Junction Presynaptic Membrane Cell Projection Synapse Presynaptic Active Zone Cytoskeleton Of Presynaptic Active Zone Extracellular Exosome Presynaptic Active Zone Cytoplasmic Component	Photoreceptor Outer Segment Extracellular Region Cell Lysosome Late Endosome Golgi Apparatus Cytosol Endomembrane System Apical Plasma Membrane Secretory Granule Dendrite Secretory Granule Membrane Multivesicular Body Membrane Weibel-Palade Body Melanosome Membrane Specific Granule Lumen Melanosome Extracellular Exosome Exocytic Vesicle
	Molecular Function	Protein Binding Rab GTPase Binding Ion Channel Binding Metal Ion Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Intracellular Protein Transport Positive Regulation Of Gene Expression Calcium Ion Regulated Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Regulation Of Membrane Potential Regulation Of Synaptic Plasticity Calcium Ion-regulated Exocytosis Of Neurotransmitter Positive Regulation Of Synaptic Transmission Spontaneous Neurotransmitter Secretion Positive Regulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Dendrite Extension Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential	Protein Targeting Intracellular Protein Transport Exocytosis Blood Coagulation Positive Regulation Of Gene Expression Antigen Processing And Presentation Melanocyte Differentiation Melanosome Localization Melanosome Transport Rab Protein Signal Transduction Multivesicular Body Organization Neutrophil Degranulation Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Positive Regulation Of Exocytosis Synaptic Vesicle Transport Positive Regulation Of Phagocytosis Multivesicular Body Sorting Pathway Complement-dependent Cytotoxicity Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Constitutive Secretory Pathway Exosomal Secretion
Pathways			Insulin processing Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases			Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Cocaine dependence ( 23958962) High density lipoprotein cholesterol levels ( 30498476) Monoclonal gammopathy of undetermined significance ( 30737484) Multiple system atrophy (pathologically confirmed) ( 27629089)	Fractional exhaled nitric oxide levels ( 25431337) Glioma ( 30714141)
Interacting Genes		13 interacting genes: ABCA1 CACNA1S PABPC1 RAB27A RAB3A RAB3B RAB3C RAB3D RAB8A RABAC1 RAPGEF4 RPH3AL YWHAH	28 interacting genes: ADRB2 APP CEP126 COPS6 EEF1A1 ERG28 EXPH5 GDF9 GDI1 GZMB LRIF1 MLPH MYO5A MYRIP RABGGTB RBM48 RIMS1 RIMS2 RPH3A RPH3AL STX1A SYTL1 SYTL2 SYTL3 SYTL4 SYTL5 UNC13D ZBTB16
Entrez ID		9699	5873
HPRD ID		09436	04845
Ensembl ID		ENSG00000176406	ENSG00000069974
Uniprot IDs		Q9UQ26	A2RU94 P51159
PDB IDs		1V27 1WFG	6HUF
Enriched GO Terms of Interacting Partners?
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