RAPGEF2 and RALGDS

Number of citations of the paper that reports this interaction (PubMedID 7809086)
71

Data Source:
BioGRID (two hybrid, pull down)

		RAPGEF2	RALGDS
Description		Rap guanine nucleotide exchange factor 2	ral guanine nucleotide dissociation stimulator
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Late Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Apical Plasma Membrane Endocytic Vesicle Protein-containing Complex Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm	Nucleus Cytosol Brush Border
	Molecular Function	Ras Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Rap Guanyl-nucleotide Exchange Factor Activity Diacylglycerol Binding PDZ Domain Binding CAMP Binding CGMP Binding Beta-1 Adrenergic Receptor Binding WW Domain Binding Phosphatidic Acid Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity
	Biological Process	MAPK Cascade Blood Vessel Development Neuron Migration G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Proliferation Positive Regulation Of Neuron Projection Development CAMP-mediated Signaling Ventricular System Development Forebrain Neuron Development Microvillus Assembly Neuron Projection Development Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Protein Binding Rap Protein Signal Transduction Intracellular Signal Transduction Nerve Growth Factor Signaling Pathway Positive Regulation Of GTPase Activity Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Protein Kinase Activity Negative Regulation Of Melanin Biosynthetic Process Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Cellular Response To CGMP Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of Vasculogenesis Positive Regulation Of Neuron Migration	Ras Protein Signal Transduction Regulation Of Catalytic Activity
Pathways		RAF/MAP kinase cascade	p38MAPK events p38MAPK events
Drugs
Diseases
GWAS		Molybdenum levels ( 26025379) Uterine fibroid number (single vs multiple) ( 30196971)	Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		12 interacting genes: CTNNB1 HSPA1A KIF5A KIF5B MAGI2 MOB4 MT-ATP8 NEDD4 RALGDS RAP1A RAP2B SPP1	23 interacting genes: AFDN ARRB1 ARRB2 CD68 CNKSR1 HRAS KRAS LRPAP1 MAPK3 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2
Entrez ID		9693	5900
HPRD ID		19358	03371
Ensembl ID		ENSG00000109756	ENSG00000160271
Uniprot IDs		Q9Y4G8	Q12967 Q8N4Y1
PDB IDs			1RAX 2B3A 2RGF 3KH0
Enriched GO Terms of Interacting Partners?
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