CD63 and ITGA6

Number of citations of the paper that reports this interaction (PubMedID 7629079)
44

Data Source:
HPRD (in vitro)

		CD63	ITGA6
Description		CD63 molecule	integrin subunit alpha 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Platelet Dense Granule Membrane Intrinsic Component Of Plasma Membrane Late Endosome Membrane Endosome Lumen Multivesicular Body Membrane Azurophil Granule Membrane Melanosome Extracellular Exosome Multivesicular Body, Internal Vesicle	Basement Membrane Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Basal Plasma Membrane Cell Surface Hemidesmosome Filopodium Integrin Alpha6-beta4 Complex
	Molecular Function	Protein Binding	Protein Binding Insulin-like Growth Factor I Binding Neuregulin Binding Laminin Binding Protein-containing Complex Binding Cadherin Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Receptor Internalization Platelet Degranulation Cell-matrix Adhesion Protein Transport Cell Migration Cellular Protein Localization Endosome To Melanosome Transport Neutrophil Degranulation Pigment Granule Maturation Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Integrin-mediated Signaling Pathway	Cell-substrate Junction Assembly Cell-matrix Adhesion Integrin-mediated Signaling Pathway Ectodermal Cell Differentiation Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Neuron Projection Development Positive Regulation Of Cell-cell Adhesion Extracellular Matrix Organization Positive Regulation Of Cell Migration Hemidesmosome Assembly Cell-substrate Adhesion Cellular Response To Extracellular Stimulus Nail Development Positive Regulation Of Phosphorylation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Skin Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Filopodium Assembly Brown Fat Cell Differentiation Leukocyte Migration Cellular Response To Organic Cyclic Compound Cell-cell Adhesion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Platelet degranulation Neutrophil degranulation	Assembly of collagen fibrils and other multimeric structures Basigin interactions Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Laminin interactions Syndecan interactions Type I hemidesmosome assembly
Drugs
Diseases			Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS		Advanced age-related macular degeneration ( 26691988) Cardiac Troponin-T levels ( 31014085)	Alzheimer's disease biomarkers ( 23419831) Blood protein levels ( 28240269) Diabetic kidney disease ( 26305897) Food allergy ( 29030101) Metabolite levels ( 23823483) Peanut allergy ( 29030101) Prostate cancer ( 31562322 19767753)
Interacting Genes		14 interacting genes: AP4M1 CD82 CD9 GLP1R HLA-DMB HLA-DRA ITGA6 PI4K2A PTGFRN SDC1 SDCBP SRF TIMP1 VKORC1	22 interacting genes: ADAM9 APP BIN1 CALM1 CANX CD151 CD36 CD63 CD82 COL17A1 GIPC1 GRB2 ITGB1 ITGB4 LGALS3BP PCSK5 PLEC PRKCD PXN RABIF RPSA TSPAN4
Entrez ID		967	3655
HPRD ID		01121	00945
Ensembl ID		ENSG00000135404	ENSG00000091409
Uniprot IDs		A0A024RB05 P08962	P23229
PDB IDs
Enriched GO Terms of Interacting Partners?
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