CD58 and DNAJA1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CD58	DNAJA1
Description		CD58 molecule	DnaJ heat shock protein family (Hsp40) member A1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Extracellular Exosome Ficolin-1-rich Granule Membrane	Nucleus Mitochondrion Cytosol Microtubule Cytoskeleton Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Cytoplasmic Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding	G Protein-coupled Receptor Binding ATPase Activator Activity Protein Binding ATP Binding Hsp70 Protein Binding Tat Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Chaperone Binding C3HC4-type RING Finger Domain Binding
	Biological Process	Heterotypic Cell-cell Adhesion Neutrophil Degranulation Leukocyte Migration Cellular Response To Interferon-gamma Cellular Response To Tumor Necrosis Factor Cell-cell Adhesion Positive Regulation Of Interleukin-8 Secretion	Protein Folding Response To Unfolded Protein Response To Heat Negative Regulation Of Protein Ubiquitination Positive Regulation Of ATPase Activity Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Regulation Of Protein Transport Protein Localization To Mitochondrion Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		Cell surface interactions at the vascular wall Neutrophil degranulation	HSP90 chaperone cycle for steroid hormone receptors (SHR)
Drugs
Diseases
GWAS		Multiple sclerosis ( 31604244 22190364 21244703 24076602 19525953 19525955 21833088 27386562) Primary biliary cholangitis ( 28425483)
Interacting Genes		4 interacting genes: APP CD2 DNAJA1 HERPUD1	22 interacting genes: ARL4D BCS1L BRCA1 CAV2 CD58 CDC16 CFTR ERG FZR1 HIVEP1 HMGCL HSPA8 LSM2 NELFCD NUDT3 PAXIP1 PGR PTEN PTTG1 SUMO4 TM4SF1 TXN
Entrez ID		965	3301
HPRD ID		01081	04159
Ensembl ID		ENSG00000116815	ENSG00000086061
Uniprot IDs		P19256	B7Z5C0 P31689
PDB IDs		1CCZ 1CI5 1QA9	2LO1 2M6Y 6E8M
Enriched GO Terms of Interacting Partners?
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