NCOR1 and SAFB

Number of citations of the paper that reports this interaction (PubMedID 16195251)
27

Data Source:
BioGRID (affinity chromatography technology, pull down, two hybrid, affinity chromatography technology)

		NCOR1	SAFB
Description		nuclear receptor corepressor 1	scaffold attachment factor B
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nuclear Chromatin Nucleus Nucleoplasm Cytosol Membrane Sin3 Complex Transcriptional Repressor Complex Mitotic Spindle	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Regulatory Region DNA Binding RNA Polymerase II Activating Transcription Factor Binding Chromatin Binding Transcription Corepressor Activity Protein Binding Nuclear Hormone Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Thyroid Hormone Receptor Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Chromatin Binding Double-stranded DNA Binding RNA Binding Protein Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Transcription By RNA Polymerase II Circadian Rhythm Regulation Of Lipid Metabolic Process Locomotor Rhythm Negative Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Fatty Acid Metabolic Process Negative Regulation Of JNK Cascade Spindle Assembly Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Intracellular Estrogen Receptor Signaling Pathway Regulation Of Growth Hormone Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Processing
Pathways		Nuclear signaling by ERBB4 Nuclear signaling by ERBB4 NR1D1 (REV-ERBA) represses gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Circadian Clock Circadian Clock Activation of anterior HOX genes in hindbrain development during early embryogenesis Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	SUMOylation of transcription cofactors
Drugs
Diseases
GWAS		C-reactive protein levels ( 30388399) FEV1 ( 30804560) Free thyroxine concentration ( 30367059) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 30804560)
Interacting Genes		86 interacting genes: ACTN2 AR ATXN1 ATXN1L ATXN3 BCL6 C1D CBFA2T2 CHD1 CHUK CLK1 CNOT2 COPS2 CSNK2A1 CXADR DACH1 DDX20 DHX30 DZIP3 ESR1 ESR2 ETS1 ETS2 GPS2 GTF2B H3C1 H4C1 HDAC3 HDAC5 HDAC9 HESX1 HEY2 HTT KLF5 MECP2 MYB MYBL2 MYOD1 NCOA1 NCOA3 NCOR2 NELFE NR1D1 NR1D2 NR1H2 NR1H3 NR2E3 NR3C1 NR6A1 PDCD2 PHB PIAS1 PML POU1F1 PPARA PPARD PPARG PTMA RARA RARG RBPJ RUNX1 RUNX1T1 RXRA SAFB SAP30 SKI SKIL SNW1 SP1 SPEN SQSTM1 TAB2 TAF6 TAF9 TBL1X TBL1XR1 THRA THRB TRIM14 TXNRD2 VDR ZBTB16 ZBTB33 ZBTB7A ZMYND11	22 interacting genes: ABHD16A CDC37 CHD1 CHD3 CLK1 CSNK2A1 CYCS ESR1 HNRNPA1 HNRNPD HNRNPK IL7R MAP1LC3B NCOR1 POLR2A SAFB2 SREK1 SRPK1 SRPK2 SRSF9 TAF15 TJP2
Entrez ID		9611	6294
HPRD ID		02911	04205
Ensembl ID		ENSG00000141027	ENSG00000160633
Uniprot IDs		A0A024RD47 O75376 Q6PGR4	B7Z2F6 B7ZLP5 Q15424
PDB IDs		2EQR 3H52 3KMZ 3N00 4MDD 4WVD
Enriched GO Terms of Interacting Partners?
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