CLOCK and CRY2

Number of citations of the paper that reports this interaction (PubMedID 23555304)
16

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		CLOCK	CRY2
Description		clock circadian regulator	cryptochrome circadian regulator 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Chromosome Cytosol Chromatoid Body Intracellular Membrane-bounded Organelle	Extracellular Region Nucleus Cytosol Nuclear Speck
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Histone Acetyltransferase Activity Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Binding Blue Light Photoreceptor Activity Phosphatase Binding FAD Binding
	Biological Process	DNA Damage Checkpoint Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Protein Acetylation Signal Transduction Spermatogenesis Circadian Rhythm Photoperiodism Histone Acetylation Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Regulation Of Insulin Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Redox State Cellular Response To Ionizing Radiation Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glucocorticoid Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Photoreactive Repair Circadian Rhythm Response To Light Stimulus Blue Light Signaling Pathway Response To Activity Protein-chromophore Linkage Negative Regulation Of Phosphoprotein Phosphatase Activity Circadian Regulation Of Gene Expression Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Transcription, DNA-templated Regulation Of Sodium-dependent Phosphate Transport Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression HATs acetylate histones Circadian Clock	Circadian Clock
Drugs
Diseases
GWAS		Height ( 25282103) Personality dimensions ( 18957941) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Axial length ( 24144296) Fasting blood glucose ( 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Glycemic traits (pleiotropy) ( 31021400) Type 2 diabetes ( 30297969) Visceral fat ( 22589738)
Interacting Genes		27 interacting genes: ARNTL ARNTL2 BHLHE41 CEP135 CRY1 CRY2 CSNK1E CSNK2B DBP DELEC1 EP300 KAT2B NPAS2 PER2 PER3 PPP1CA PPP1CB PPP1CC PPP2R1B PPP2R5D PPP2R5E RARA RHOA RORB RORC RXRA SIRT1	22 interacting genes: ATXN1 BHLHE41 BRCA1 CLOCK CTBP1 DELEC1 EZH2 LMNA MTUS2 NPAS2 PDE9A PER1 PER2 PER3 PPP2R1B PPP2R5D PPP2R5E PPP5C PTGES2 STK11 TIMELESS TTC1
Entrez ID		9575	1408
HPRD ID		03508	07226
Ensembl ID		ENSG00000134852	ENSG00000121671
Uniprot IDs		O15516 Q3ZCT4 Q53EU0	A0A0D2X7Z3 A2I2P1 Q49AN0
PDB IDs		4H10 6QPJ
Enriched GO Terms of Interacting Partners?
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