SIGLEC6 and LEP

Number of citations of the paper that reports this interaction (PubMedID 10428856)
29

Data Source:
HPRD (in vitro)

		SIGLEC6	LEP
Description		sialic acid binding Ig like lectin 6	leptin
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Membrane	Extracellular Region Extracellular Space Cytosol
	Molecular Function	Protein Binding Carbohydrate Binding Sialic Acid Binding	DNA Binding Hormone Activity Peptide Hormone Receptor Binding Leptin Receptor Binding
	Biological Process	Cell Adhesion Cell-cell Signaling	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Ovulation From Ovarian Follicle Response To Hypoxia Placenta Development Positive Regulation Of Protein Phosphorylation Regulation Of Endothelial Cell Proliferation Response To Dietary Excess Cardiac Muscle Hypertrophy Glucose Metabolic Process Regulation Of Gluconeogenesis Energy Reserve Metabolic Process Glycerol Biosynthetic Process Lipid Metabolic Process Fatty Acid Beta-oxidation Phagocytosis Tyrosine Phosphorylation Of STAT Protein Female Pregnancy Circadian Rhythm Cholesterol Metabolic Process Bile Acid Metabolic Process Regulation Of Blood Pressure Determination Of Adult Lifespan Adult Feeding Behavior Negative Regulation Of Autophagy Negative Regulation Of Lipid Storage Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Activity Sexual Reproduction Central Nervous System Neuron Development Insulin Secretion T Cell Differentiation Regulation Of Intestinal Cholesterol Absorption Positive Regulation Of TOR Signaling Negative Regulation Of Appetite Prostaglandin Secretion Response To Estradiol Interleukin-12 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Natural Killer Cell Activation Regulation Of Natural Killer Cell Proliferation Response To Insulin Cellular Response To Insulin Stimulus Response To Vitamin E Leptin-mediated Signaling Pathway Positive Regulation Of Luteinizing Hormone Secretion Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Intracellular Signal Transduction Bone Mineralization Involved In Bone Maturation Aorta Development Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Protein Import Into Nucleus Hormone Metabolic Process Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Glucose Homeostasis Eating Behavior Negative Regulation Of Apoptotic Process Positive Regulation Of Ion Transport Positive Regulation Of MAPK Cascade Cellular Response To Leptin Stimulus Response To Ethanol Regulation Of Angiogenesis Negative Regulation Of Vasoconstriction Negative Regulation Of Glucose Import Positive Regulation Of JAK-STAT Cascade Positive Regulation Of Insulin Receptor Signaling Pathway Regulation Of Bone Remodeling Positive Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Developmental Growth Regulation Of Insulin Secretion Regulation Of Steroid Biosynthetic Process Intestinal Absorption Leukocyte Tethering Or Rolling Regulation Of Nitric-oxide Synthase Activity Elastin Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Protein Kinase B Signaling Regulation Of Lipoprotein Lipid Oxidation Adipose Tissue Development Negative Regulation Of Cartilage Development Negative Regulation Of Glucagon Secretion Cellular Response To L-ascorbic Acid Cellular Response To Retinoic Acid Interleukin-6 Secretion Interleukin-8 Secretion Regulation Of Brown Fat Cell Differentiation Bone Growth Positive Regulation Of Cold-induced Thermogenesis Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of P38MAPK Cascade Positive Regulation Of Fat Cell Apoptotic Process Activation Of Protein Kinase C Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Glutamine Transport Positive Regulation Of Hepatic Stellate Cell Activation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Signaling by Leptin Transcriptional regulation of white adipocyte differentiation Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and deacylation of Ghrelin
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 28240269) Carotid intima media thickness ( 26343869)	BMI at 1.5 years old ( 31575865) BMI at 8 months old ( 31575865) circulating leptin levels ( 26833098) circulating leptin levels adjusted for BMI ( 26833098) High density lipoprotein cholesterol levels ( 29403010) Type 2 diabetes ( 26818947 23945395)
Interacting Genes		4 interacting genes: FHL2 LEP LGALS3BP TCF4	9 interacting genes: A2M CLU CRP GHRL HK3 LEPR PRKAA2 SIGLEC6 UCN
Entrez ID		946	3952
HPRD ID		16058	01249
Ensembl ID		ENSG00000105492	ENSG00000174697
Uniprot IDs		A0A024R4K4 O43699	A4D0Y8 P41159
PDB IDs			1AX8
Enriched GO Terms of Interacting Partners?
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