EIF2AK3 and EIF2S1

Number of citations of the paper that reports this interaction (PubMedID 9819435)
249

Data Source:
HPRD (in vivo, in vitro)

		EIF2AK3	EIF2S1
Description		eukaryotic translation initiation factor 2 alpha kinase 3	eukaryotic translation initiation factor 2 subunit alpha
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm	Nucleus Cytosol Polysome Eukaryotic Translation Initiation Factor 2 Complex Eukaryotic Translation Initiation Factor 2B Complex Cytoplasmic Stress Granule Membrane Eukaryotic 48S Preinitiation Complex Multi-eIF Complex Translation Initiation Ternary Complex Synapse Extracellular Exosome Glial Limiting End-foot
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Protein Binding ATP Binding Enzyme Binding Protein Phosphatase Binding Identical Protein Binding Hsp90 Protein Binding	RNA Binding Translation Initiation Factor Activity Protein Binding Ribosome Binding
	Biological Process	Skeletal System Development Ossification Angiogenesis Chondrocyte Development Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process ER Overload Response Endoplasmic Reticulum Organization Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Negative Regulation Of Translation Peptidyl-serine Phosphorylation Calcium-mediated Signaling Bone Mineralization Endoplasmic Reticulum Unfolded Protein Response Endocrine Pancreas Development Negative Regulation Of Myelination Negative Regulation Of Translational Initiation In Response To Stress Cellular Response To Amino Acid Starvation Response To Endoplasmic Reticulum Stress EiF2alpha Phosphorylation In Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Cellular Response To Glucose Starvation Positive Regulation Of Transcription By RNA Polymerase I Protein Autophosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Cellular Response To Cold Positive Regulation Of Protein Localization To Nucleus Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Manganese-induced Endoplasmic Reticulum Stress	Translational Initiation Aging Negative Regulation Of Translational Initiation In Response To Stress Stress Granule Assembly Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To UV Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Protein Autophosphorylation Transmembrane Transport Positive Regulation Of Neuron Death Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Response To Manganese-induced Endoplasmic Reticulum Stress Positive Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		PERK regulates gene expression	L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Diseases		Wolcott-Rallison syndrome; SED, Wolcott-Rallison type Permanent neonatal diabetes mellitus (PNDM)
GWAS		Adverse response to drug ( 30420678) Chronotype ( 30696823) Height ( 20881960 25282103 25429064 31562340) Progressive supranuclear palsy ( 21685912)
Interacting Genes		6 interacting genes: DNAJC3 EIF2S1 HSP90AA1 HSPA5 IKBKB NFE2L2	24 interacting genes: CASP3 CASP6 CDC37 CSNK2A1 EIF1AX EIF2AK1 EIF2AK2 EIF2AK3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2S2 HSP90AA1 HSPB1 MELK P4HB PPP1R15A PRKCA PRKCD PRMT7 SFN TERT THAP12
Entrez ID		9451	1965
HPRD ID		04942	04881
Ensembl ID		ENSG00000172071	ENSG00000134001
Uniprot IDs		B3KY45 Q68DI6 Q9NZJ5	P05198 Q53XC0
PDB IDs		4G31 4G34 4M7I 4X7H 4X7J 4X7K 4X7L 4X7N 4X7O 4YZS 5SV7	1KL9 1Q8K 6K71 6K72 6O81 6O85 6O9Z
Enriched GO Terms of Interacting Partners?
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