TNFSF8 and TNFRSF8

Number of citations of the paper that reports this interaction (PubMedID 11754357)
13

Data Source:
HPRD (in vitro)

		TNFSF8	TNFRSF8
Description		TNF superfamily member 8	TNF receptor superfamily member 8
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane	Cytoplasm Plasma Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding	Transmembrane Signaling Receptor Activity
	Biological Process	Immune Response Cell-cell Signaling Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of T Cell Proliferation CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-positive Bacterium	Signal Transduction Negative Regulation Of Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Apoptotic Process Positive Regulation Of TRAIL Biosynthetic Process Cellular Response To Mechanical Stimulus
Pathways		TNFs bind their physiological receptors	TNFs bind their physiological receptors
Drugs			Brentuximab vedotin
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Crohn's disease ( 30500874 21102463 23266558) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) IgA levels ( 28628107) Inflammatory bowel disease ( 27569725 23128233) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Primary biliary cholangitis ( 28425483 30643196) Sum eosinophil basophil counts ( 27863252) Ulcerative colitis ( 21297633)	Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252) Tuberculosis ( 29036319)
Interacting Genes		2 interacting genes: ANG TNFRSF8	7 interacting genes: ALK TDP2 TNFSF8 TRAF1 TRAF2 TRAF3 TRAF5
Entrez ID		944	943
HPRD ID		04852	01074
Ensembl ID		ENSG00000106952	ENSG00000120949
Uniprot IDs		A0A087X228 P32971 Q52M88	A5D8T4 P28908
PDB IDs			1D01
Enriched GO Terms of Interacting Partners?
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