SYTL4 and RAB27A

Number of citations of the paper that reports this interaction (PubMedID 11865063)
65

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		SYTL4	RAB27A
Description		synaptotagmin like 4	RAB27A, member RAS oncogene family
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GO Annotations	Cellular Component	Endosome Plasma Membrane Extrinsic Component Of Membrane Transport Vesicle Membrane Platelet Alpha Granule Membrane Exocytic Vesicle	Photoreceptor Outer Segment Extracellular Region Cell Lysosome Late Endosome Golgi Apparatus Cytosol Endomembrane System Apical Plasma Membrane Secretory Granule Dendrite Secretory Granule Membrane Multivesicular Body Membrane Weibel-Palade Body Melanosome Membrane Specific Granule Lumen Melanosome Extracellular Exosome Exocytic Vesicle
	Molecular Function	Protein Binding Phospholipid Binding Rab GTPase Binding Neurexin Family Protein Binding Metal Ion Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Plasma Membrane Repair Platelet Degranulation Intracellular Protein Transport Exocytosis Lysosome Localization Positive Regulation Of Exocytosis Negative Regulation Of Insulin Secretion Positive Regulation Of Protein Secretion Multivesicular Body Sorting Pathway Regulation Of Plasma Membrane Repair	Protein Targeting Intracellular Protein Transport Exocytosis Blood Coagulation Positive Regulation Of Gene Expression Antigen Processing And Presentation Melanocyte Differentiation Melanosome Localization Melanosome Transport Rab Protein Signal Transduction Multivesicular Body Organization Neutrophil Degranulation Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Positive Regulation Of Exocytosis Synaptic Vesicle Transport Positive Regulation Of Phagocytosis Multivesicular Body Sorting Pathway Complement-dependent Cytotoxicity Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Constitutive Secretory Pathway Exosomal Secretion
Pathways		Platelet degranulation	Insulin processing Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs		Insulin Human Insulin Pork
Diseases			Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Lean body mass ( 28552196)	Fractional exhaled nitric oxide levels ( 25431337) Glioma ( 30714141)
Interacting Genes		12 interacting genes: CCDC85B CEP70 FXR2 HMG20A INS RAB27A RAB27B RAB3A RAB8A STX1A STXBP1 ZBTB7B	28 interacting genes: ADRB2 APP CEP126 COPS6 EEF1A1 ERG28 EXPH5 GDF9 GDI1 GZMB LRIF1 MLPH MYO5A MYRIP RABGGTB RBM48 RIMS1 RIMS2 RPH3A RPH3AL STX1A SYTL1 SYTL2 SYTL3 SYTL4 SYTL5 UNC13D ZBTB16
Entrez ID		94121	5873
HPRD ID		06735	04845
Ensembl ID		ENSG00000102362	ENSG00000069974
Uniprot IDs		A0A024RCF8 A8K973 B2R7R4 Q71SF7 Q96C24	A2RU94 P51159
PDB IDs		2CSZ 3FDW 5X6T	6HUF
Enriched GO Terms of Interacting Partners?
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