NRXN1 and NXPH1

Number of citations of the paper that reports this interaction (PubMedID 9856994)
48

Data Source:
HPRD (in vitro, in vivo)

		NRXN1	NXPH1
Description		neurexin 1	neurexophilin 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleolus Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Cell Junction Nuclear Membrane Vesicle Protein-containing Complex Presynaptic Membrane Cell Projection Neuronal Cell Body Schaffer Collateral - CA1 Synapse Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Presynaptic Active Zone Membrane	Extracellular Region
	Molecular Function	Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Acetylcholine Receptor Binding Signaling Receptor Activity Cell Adhesion Molecule Binding Neuroligin Family Protein Binding	Signaling Receptor Binding
	Biological Process	Neuron Cell-cell Adhesion Chemical Synaptic Transmission Neurotransmitter Secretion Axon Guidance Synapse Assembly Learning Adult Behavior Social Behavior Vocal Learning Neuromuscular Process Controlling Balance Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Vocalization Behavior Positive Regulation Of Synapse Maturation Postsynaptic Membrane Assembly Gephyrin Clustering Involved In Postsynaptic Density Assembly Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering Regulation Of Synaptic Vesicle Cycle Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling By Endocannabinoid Synaptic Membrane Adhesion Regulation Of Presynapse Assembly Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Grooming Behavior
Pathways		Neurexins and neuroligins Neurexins and neuroligins Non-integrin membrane-ECM interactions Neurexins and neuroligins Neurexins and neuroligins
Drugs		Calcium Citrate Calcium Phosphate
Diseases		Pitt-Hopkins syndrome, including: Pitt-Hopkins syndrome; Pitt-Hopkins-like syndrome
GWAS		Body mass index ( 28892062) Chromosomal aberration frequency (chromatid type) ( 31586183) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Educational attainment ( 25201988) General risk tolerance (MTAG) ( 30643258) Isovolumetric relaxation time ( 28394258) Lateral ventricle temporal horn volume ( 31530798) Longevity ( 20834067) Lung cancer in ever smokers ( 28604730) Metabolite levels (HVA/MHPG ratio) ( 23319000) Morning person ( 30696823) Personality dimensions ( 20691247) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive astigmatism ( 25367360) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Severe gingival inflammation ( 28459102) Systolic blood pressure ( 30224653 30578418) Temperament ( 22832960) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Word spelling ( 30741946)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Brain imaging ( 20100581) Idiopathic dilated cardiomyopathy ( 29495422) Metabolite levels ( 23823483) Neuroticism ( 18762592) Obesity-related traits ( 23251661) Protein quantitative trait loci ( 18464913) Response to fenofibrate ( 22890011) Response to long-chain n-3 polyunsaturated fatty acid supplementation (change in triglyceride levels) ( 24847101) Waist-to-hip ratio adjusted for body mass index ( 27195708) Working memory ( 31598132)
Interacting Genes		29 interacting genes: AFDN APBA1 APBA2 ATP13A2 CASK MACF1 MYO16 NLGN1 NLGN2 NLGN3 NXPH1 NXPH2 NXPH3 PDZD2 RPH3A RTN4 SDCBP2 SIPA1L1 SYT1 SYT13 SYT2 SYT4 SYT5 SYT6 SYT7 SYT9 SYTL1 SYTL2 SYTL3	1 interacting genes: NRXN1
Entrez ID		9378	30010
HPRD ID		11858	06867
Ensembl ID		ENSG00000179915	ENSG00000122584
Uniprot IDs		A0A0D9SEM5 A0A0D9SEQ7 A0A1D5RMU6 E7EQN4 E7ERL8 H0Y568 H7BYC7 P58400 Q9ULB1	P58417 Q3LID8
PDB IDs		3B3Q 5Z8Y
Enriched GO Terms of Interacting Partners?
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