SLC9A3R1 and NOS2

Number of citations of the paper that reports this interaction (PubMedID 12080081)
14

Data Source:
HPRD (in vitro, in vivo)

		SLC9A3R1	NOS2
Description		SLC9A3 regulator 1	nitric oxide synthase 2
Image
GO Annotations	Cellular Component	Ruffle Cell Nucleus Cytoplasm Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Stereocilium Tip Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Sperm Midpiece	Cell Nucleus Cytoplasm Peroxisome Peroxisomal Matrix Cytosol Plasma Membrane Vesicle Membrane Cortical Cytoskeleton Perinuclear Region Of Cytoplasm
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-catenin Binding Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Protein Self-association Protein-containing Complex Binding Myosin II Binding Protein N-terminus Binding Dopamine Receptor Binding Molecular Adaptor Activity Growth Factor Receptor Binding	NADPH-hemoprotein Reductase Activity Nitric-oxide Synthase Activity Protein Binding Calmodulin Binding FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Tetrahydrobiopterin Binding Arginine Binding Protein Homodimerization Activity Metal Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding
	Biological Process	Renal Sodium Ion Transport Nuclear Migration Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Sound Negative Regulation Of Cell Proliferation Regulation Of Cell Shape Regulation Of Cell Size Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Wnt Signaling Pathway Gland Morphogenesis Microvillus Assembly Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium:proton Antiporter Activity Bile Acid Secretion Glutathione Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Excretion Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Establishment Of Golgi Localization Negative Regulation Of Protein Kinase B Signaling Auditory Receptor Cell Stereocilium Organization Phospholipase C-activating Dopamine Receptor Signaling Pathway Protein-containing Complex Assembly Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Renal Phosphate Ion Absorption Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Response To Hypoxia Positive Regulation Of Leukocyte Mediated Cytotoxicity Innate Immune Response In Mucosa Arginine Catabolic Process Protein Targeting To Peroxisome Superoxide Metabolic Process Nitric Oxide Biosynthetic Process Nitric Oxide Mediated Signal Transduction Circadian Rhythm Response To Bacterium Response To Hormone Negative Regulation Of Gene Expression Peptidyl-cysteine S-nitrosylation Cytokine-mediated Signaling Pathway Positive Regulation Of Guanylate Cyclase Activity Prostaglandin Secretion Response To Lipopolysaccharide Cellular Response To Drug Regulation Of Cell Proliferation Negative Regulation Of Protein Catabolic Process Defense Response To Bacterium Regulation Of Cellular Respiration Cell Redox Homeostasis Negative Regulation Of Blood Pressure Regulation Of Insulin Secretion Defense Response To Gram-negative Bacterium Positive Regulation Of Killing Of Cells Of Other Organism Oxidation-reduction Process Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Interleukin-6 Secretion Interleukin-8 Secretion Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways			ROS and RNS production in phagocytes Nitric oxide stimulates guanylate cyclase Interleukin-4 and Interleukin-13 signaling Peroxisomal protein import Peroxisomal protein import Inhibition of nitric oxide production
Drugs			L-Arginine L-Citrulline Miconazole Dexamethasone N,N-dimethylarginine 4r-Fluoro-N6-Ethanimidoyl-L-Lysine 3-Bromo-7-Nitroindazole N-(3-(Aminomethyl)Benzyl)Acetamidine 7-Nitroindazole S-Ethylisothiourea Thiocoumarin N-Omega-Propyl-L-Arginine 6-Nitroindazole N-Omega-Hydroxy-L-Arginine Imidazole N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine L-Thiocitrulline L-erythro-7,8-dihydrobiopterin 5-Nitroindazole KD7040 ACCLAIM Pimagedine 5-(4'-AMINO-1'-ETHYL-5',8'-DIFLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-D-PROLINAMIDE 4-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrile (2S)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine (3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINE (3S)-1-(1,3-BENZODIOXOL-5-YLMETHYL)-3-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PIPERIDINE 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-6-METHYLPYRIMIDINE ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDE ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL]-4-CYANOBENZAMIDE 1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[PIPERIDINE-4,2'(1'H)-QUINAZOLINE]-4'-AMINE 4-(1H-IMIDAZOL-1-YL)PHENOL 1-[4-(AMINOMETHYL)BENZOYL]-5'-FLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLIN]-4'-AMINE Triflusal
Diseases		Nephrolithiasis/osteoporosis, hypophosphatemic	Esophageal cancer
GWAS		Dental caries (decayed and filled deciduous teeth) ( 31533690) Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690) Fibrinogen ( 20031577) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252)	Ankylosing spondylitis ( 23749187 30946743) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 23128233) Cutaneous psoriasis ( 26626624) Fractional exhaled nitric oxide (childhood) ( 24315451) Inflammatory skin disease ( 25574825) Psoriasis ( 25903422 20953189 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624)
Interacting Genes		64 interacting genes: ABCC2 ABCC4 ADRB2 AKAP10 AKT1 ATP6V1B1 ATP6V1E1 AXIN2 BCL10 BCL2A1 CABP1 CD300A CFTR CLCN3 CNGA2 COG1 CTNNB1 EGFR EZR GC GFI1 GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PDZK1 PHLPP1 PLCB1 PLCB2 PRKCA PTEN PTH1R RDX RLBP1 SCN4A SKP2 SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A7 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 ST6GALNAC2 TBC1D10A TRPC4 TRPC5 YAP1 YES1 ZNF468	12 interacting genes: AATF ACTB ACTN4 CAV1 PEX5 RAC1 RAC2 SLC9A3R1 SPSB1 SPSB2 SPSB4 SRC
Entrez ID		9368	4843
HPRD ID		05406	01225
Ensembl ID		ENSG00000109062	ENSG00000007171
Uniprot IDs		O14745	P35228
PDB IDs		1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF 4JL7 4LMM 4MPA 4N6X 4PQW 4Q3H	1NSI 2LL6 2NSI 3E7G 3EJ8 3HR4 4CX7 4NOS 5TP6 5XN3
Enriched GO Terms of Interacting Partners?
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