RPL23 and DAPP1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		RPL23	DAPP1
Description		ribosomal protein L23	dual adaptor of phosphotyrosine and 3-phosphoinositides 1
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Postsynaptic Density Membrane Cytosolic Large Ribosomal Subunit Protein-containing Complex Extracellular Exosome	Cytosol Plasma Membrane
	Molecular Function	Transcription Coactivator Binding RNA Binding Structural Constituent Of Ribosome Protein Binding Ubiquitin Protein Ligase Binding Large Ribosomal Subunit RRNA Binding Ubiquitin Ligase Inhibitor Activity	Protein Binding Phospholipid Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Ribosomal Protein Import Into Nucleus SRP-dependent Cotranslational Protein Targeting To Membrane Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Viral Transcription Protein-DNA Complex Disassembly Protein Stabilization Negative Regulation Of Cell Cycle Arrest Positive Regulation Of Cell Cycle Arrest Cellular Response To Actinomycin D Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Protein Dephosphorylation Signal Transduction
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Anisomycin Puromycin	Inositol 1,3,4,5-Tetrakisphosphate
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561)
Interacting Genes		10 interacting genes: APP BCCIP CDC42 CLU DAPP1 EPS8L2 GRWD1 IPO5 PTEN RELA	21 interacting genes: BTK CNDP2 ERBB3 FCHSD2 GSTCD HSD3B7 HSPA1A LCK LYN MAP4K1 MGARP MYLIP PLAGL2 PLCG1 PLCG2 RBP7 RPL23 SRC TM4SF19 TNFAIP1 ZNHIT1
Entrez ID		9349	27071
HPRD ID		04716	05773
Ensembl ID		ENSG00000125691	ENSG00000070190
Uniprot IDs		A0A024R1Q8 P62829	J3KNB3 Q9UN19
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6QZP	1FAO 1FB8
Enriched GO Terms of Interacting Partners?
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