CD163 and HP

Number of citations of the paper that reports this interaction (PubMedID 11854028)
51

Data Source:
HPRD (in vivo)

		CD163	HP
Description		CD163 molecule	haptoglobin
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endocytic Vesicle Membrane	Extracellular Region Extracellular Space Haptoglobin-hemoglobin Complex Specific Granule Lumen Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Tertiary Granule Lumen
	Molecular Function	Scavenger Receptor Activity Protein Binding	Serine-type Endopeptidase Activity Protein Binding Antioxidant Activity Hemoglobin Binding
	Biological Process	Receptor-mediated Endocytosis Acute-phase Response	Acute Inflammatory Response Proteolysis Receptor-mediated Endocytosis Defense Response Acute-phase Response Response To Organic Substance Positive Regulation Of Cell Death Response To Hydrogen Peroxide Defense Response To Bacterium Neutrophil Degranulation Negative Regulation Of Oxidoreductase Activity Cellular Oxidant Detoxification Negative Regulation Of Hydrogen Peroxide Catabolic Process
Pathways		Scavenging of heme from plasma CD163 mediating an anti-inflammatory response	Scavenging of heme from plasma Neutrophil degranulation
Drugs		WF10
Diseases
GWAS		Creatine kinase levels ( 29403010) HDL cholesterol levels ( 28334899) Hematological and biochemical traits ( 20139978) High density lipoprotein cholesterol levels ( 29083408)	Blood protein levels ( 30072576 29875488 28240269) Cholesterol, total ( 25961943 20686565) Haptoglobin levels ( 22403646) LDL cholesterol ( 25961943 20686565) Low density lipoprotein cholesterol levels ( 29403010) Metabolite levels ( 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Morning person ( 30696823) Plasma haptoglobin levels in type 2 diabetes ( 29572449) Total cholesterol levels ( 29403010) Urinary haptoglobin levels in type 2 diabetes ( 29572449)
Interacting Genes		5 interacting genes: CSNK2B ERC1 HP MYH9 PRKCA	21 interacting genes: ADAMTS4 APOA1 ATP7B C1RL CD163 CD22 GADD45G GRB2 HBB ITGAM ITGB2 LAMC3 MVP RBBP6 RPL11 SMAD3 TBL1X TGM2 TP63 VKORC1 WASL
Entrez ID		9332	3240
HPRD ID		05708	00772
Ensembl ID		ENSG00000177575	ENSG00000257017
Uniprot IDs		Q86VB7	A0A0C4DGL8 P00738 Q6PEJ8
PDB IDs			4WJG 4X0L 5HU6
Enriched GO Terms of Interacting Partners?
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