CD6 and NFE2L1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		CD6	NFE2L1
Description		CD6 molecule	nuclear factor, erythroid 2 like 1
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Extracellular Space Integral Component Of Plasma Membrane External Side Of Plasma Membrane Extracellular Matrix Intrinsic Component Of Plasma Membrane T Cell Receptor Complex	Nuclear Chromatin Cell Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Integral Component Of Membrane Protein-containing Complex
	Molecular Function	Lipopolysaccharide Binding Scavenger Receptor Activity Protein Binding Identical Protein Binding Lipoteichoic Acid Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Coregulator Activity Protein Binding Cholesterol Binding Protein Domain Specific Binding Protein-containing Complex Binding Promoter-specific Chromatin Binding
	Biological Process	Immunological Synapse Formation Adaptive Immune Response Acute Inflammatory Response To Antigenic Stimulus Endocytosis Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Lipopolysaccharide-mediated Signaling Pathway Response To Lipopolysaccharide Positive Regulation Of T Cell Proliferation Innate Immune Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response	Protein Polyubiquitination Fructose 6-phosphate Metabolic Process Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Glutathione Metabolic Process Heme Biosynthetic Process Inflammatory Response Regulation Of Mitotic Nuclear Division Cholesterol Metabolic Process Anatomical Structure Morphogenesis Regulation Of Glucose Metabolic Process Regulation Of Fatty Acid Metabolic Process Cellular Homeostasis Spinal Cord Motor Neuron Differentiation Glial Cell Fate Commitment Erythrocyte Differentiation Cellular Response To Oxidative Stress Response To Endoplasmic Reticulum Stress Cholesterol Homeostasis Cysteine Transport Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Glucose 6-phosphate Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Cold Cellular Response To Copper Ion Cellular Response To Cholesterol Regulation Of Nucleus Organization Regulation Of Response To Endoplasmic Reticulum Stress
Pathways
Drugs			Lauryl Dimethylamine-N-Oxide
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Gut microbiota (bacterial taxa) ( 27694959) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908 23128233) Multiple sclerosis ( 31604244 21244703 24076602 19525953 21833088) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Generalized epilepsy ( 22949513) Heel bone mineral density ( 30598549)
Interacting Genes		5 interacting genes: ALCAM CD5 GYG1 NFE2L1 SDCBP	15 interacting genes: ATF4 BACH2 CAPN1 CD6 CREBZF GSK3B HCFC1 JUN JUNB JUND MAFF MAFG MAFK NFE2L3 PARVA
Entrez ID		923	4779
HPRD ID		01724	01223
Ensembl ID		ENSG00000013725	ENSG00000082641
Uniprot IDs		P30203 Q6AZ88 Q8N4Q7	J9JIE5 Q14494 Q8NF22
PDB IDs		5A2E
Enriched GO Terms of Interacting Partners?
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