CD247 and ZNF281

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		CD247	ZNF281
Description		CD247 molecule	zinc finger protein 281
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex	Nucleus Nucleoplasm
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Tyrosine Kinase Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Adaptive Immune Response Interleukin-2 Production Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of Protein Localization To Cell Surface	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Embryonic Body Morphogenesis Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Stem Cell Differentiation
Pathways
Drugs		Muromonab
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Asthma ( 31361310 30929738 27182965 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Celiac disease ( 20190752) Celiac disease or Rheumatoid arthritis ( 21383967) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Medication use (thyroid preparations) ( 31015401) Pre-treatment viral load in HIV-1 infection ( 31219150) Rheumatoid arthritis ( 20453842) Systemic sclerosis ( 21750679 31672989 20383147 29293537 21779181)	Antisaccade task score ( 31596458) Myopia ( 27182965) Neurofibrillary tangles ( 31497858) Prepulse inhibition of the startle response ( 31596458)
Interacting Genes		38 interacting genes: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281	7 interacting genes: CD247 EGLN1 FBXW11 MYC PIK3R3 STAT3 ZBTB16
Entrez ID		919	23528
HPRD ID		01729	11702
Ensembl ID		ENSG00000198821	ENSG00000162702
Uniprot IDs		P20963	B3KMX4 Q9Y2X9
PDB IDs		1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ 4XZ1 6JXR
Enriched GO Terms of Interacting Partners?
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