BUB3 and EXOC3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		BUB3	EXOC3
Description		BUB3 mitotic checkpoint protein	exocyst complex component 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nucleoplasm Cytosol Mitotic Checkpoint Complex Bub1-bub3 Complex	Exocyst Golgi Apparatus Cytosol Growth Cone Midbody Secretory Granule Membrane Presynaptic Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Ubiquitin Binding	SNARE Binding Protein Binding Cadherin Binding
	Biological Process	Mitotic Sister Chromatid Segregation Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Attachment Of Spindle Microtubules To Kinetochore Anaphase-promoting Complex-dependent Catabolic Process Protein Localization To Kinetochore Cell Division Meiotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition	Exocytosis Protein Transport Exocyst Localization
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		Body mass index ( 28892062) Menopause (age at onset) ( 24045676) Right lateral prefrontal cortical growth ( 29682794)	Hemoglobin concentration ( 27863252) Hypospadias ( 25108383) Ulcerative colitis ( 21297633)
Interacting Genes		16 interacting genes: BUB1 BUB1B CPNE1 EXOC3 HDAC1 HDAC2 PARP1 PARP2 PSTPIP1 RPL37A SUGT1 THRA TOP1 UBA1 UBR5 WBP4	7 interacting genes: APP BIRC6 BUB3 EXOC2 MLH1 RALA VAMP2
Entrez ID		9184	11336
HPRD ID		04761	09738
Ensembl ID		ENSG00000154473	ENSG00000180104
Uniprot IDs		A0A140VJF3 O43684	A0A024QYZ6 O60645 Q69YP2
PDB IDs
Enriched GO Terms of Interacting Partners?
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