ACY3 and PIAS2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ACY3	PIAS2
Description		aminoacylase 3	protein inhibitor of activated STAT 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Apical Plasma Membrane Extracellular Exosome	Nucleus Nucleoplasm PML Body Nuclear Speck
	Molecular Function	Molecular_function Aminoacylase Activity Protein Binding Hydrolase Activity, Acting On Ester Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Identical Protein Binding Metal Ion Binding	RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity
	Biological Process	Xenobiotic Metabolic Process Biological_process Viral Process	Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Androgen Receptor Signaling Pathway
Pathways		Aflatoxin activation and detoxification	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs		L-Aspartic Acid
Diseases
GWAS		Serum metabolite levels ( 24625756) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		14 interacting genes: AAMDC ASPA GORASP2 KRTAP10-3 KRTAP10-8 LNX1 MAP3K8 NEDD4L NOTCH2NLA PIAS2 PLEKHF2 PMM2 RARG RRAS	72 interacting genes: ACY3 ADA AKT1 AR C1QA CCHCR1 CCNDBP1 CDCA8 CHMP4B CLDN2 CREBBP CTBP1 DDX39B DNMT3A ELK1 ESR1 ESR2 FLI1 GFAP GLUL GOLGA2 GRM8 GTF2I GTF2IRD1 HDAC3 HUWE1 JUN LMNA LMNB1 MAPK8 MAPKAPK2 MBD1 MITF MSX2 MX2 NAV2 NR3C1 PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 RUFY1 SIAH1 SIAH2 SMAD3 SMAD4 SNAI2 SNIP1 SREBF2 STAT4 SUMO1 SUMO1P1 SUMO2 SUMO3 TICAM2 TP53 TRIM23 TRIM27 TRIM55 TRIM63 TSR2 UBE2I UBE2L3 ZBED1 ZBTB8A ZNF451
Entrez ID		91703	9063
HPRD ID		12422	06944
Ensembl ID		ENSG00000132744	ENSG00000078043
Uniprot IDs		A0A024R5L2 Q96HD9	A0A024RC49 O75928 Q2TA77
PDB IDs			2ASQ 4FO9
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?