HGS and GOLGA2

Number of citations of the paper that reports this interaction (PubMedID 26871637)
108

Data Source:
BioGRID (two hybrid)

		HGS	GOLGA2
Description		hepatocyte growth factor-regulated tyrosine kinase substrate	golgin A2
Image
GO Annotations	Cellular Component	Lysosome Endosome Early Endosome Cytosol Early Endosome Membrane Multivesicular Body Membrane ESCRT-0 Complex Intracellular Membrane-bounded Organelle Extracellular Exosome	Golgi Cis Cisterna Golgi Membrane Spindle Pole Golgi Apparatus Cis-Golgi Network Microtubule COPII-coated ER To Golgi Transport Vesicle Golgi Cisterna Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Mitotic Spindle
	Molecular Function	Protein Binding Protein Domain Specific Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding	Protein Binding Microtubule Binding Protein Kinase Binding Syntaxin Binding Identical Protein Binding Cadherin Binding Importin-alpha Family Protein Binding
	Biological Process	Protein Targeting To Lysosome Signal Transduction Negative Regulation Of Cell Proliferation Membrane Invagination Positive Regulation Of Gene Expression Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Endosomal Transport Macroautophagy Negative Regulation Of Angiogenesis Protein Deubiquitination Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Multivesicular Body Assembly Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of MAP Kinase Activity Negative Regulation Of JAK-STAT Cascade Membrane Organization Protein Localization To Membrane Positive Regulation Of Exosomal Secretion	Protein Glycosylation ER To Golgi Vesicle-mediated Transport Microtubule Nucleation Golgi Organization Centrosome Cycle Asymmetric Cell Division Negative Regulation Of Autophagy Protein Transport Negative Regulation Of Protein Binding COPII Vesicle Coating Spindle Assembly Protein Homotetramerization Positive Regulation Of Protein Glycosylation Golgi Ribbon Formation Golgi Disassembly Spindle Assembly Involved In Meiosis Mitotic Spindle Assembly Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways		EGFR downregulation Lysosome Vesicle Biogenesis Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell Endosomal Sorting Complex Required For Transport (ESCRT) Inhibition of membrane repair Prevention of phagosomal-lysosomal fusion	Golgi Cisternae Pericentriolar Stack Reorganization Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs		Citric Acid
Diseases
GWAS		Eye color traits ( 20463881)	Body mass index ( 26426971)
Interacting Genes		182 interacting genes: ABI2 ACLY AHCYL1 APC APLP2 APP ARFIP2 ARL6IP1 ATP1A1 ATP2A2 ATXN1L BCAS2 BEGAIN BRINP3 BSG C1orf94 CASK CBS CCDC103 CCDC114 CCDC136 CCDC33 CDR2 CEP55 CEP57L1 CEP63 CLTC COG8 CRMP1 CRX CSNK2A1 CSTF2 CSTF2T CTTNBP2NL DAZAP2 DCTN2 DECR1 DEUP1 DGCR6 DLG4 DNAJC5 DYDC1 EGFR EHMT2 EPS15 ESRRG EXOC5 EXOC7 EXOC8 FAM168A FANCG FCHSD2 FLOT1 FLOT2 GFAP GFI1B GGA2 GKAP1 GOLGA2 HAP1 HNRNPDL HSFY1 HSPA8 IL2RB IL4R ILKAP ING5 INTS4 JAKMIP2 KIAA0753 KRT13 KRT15 KRT18 KRT19 KRT31 KRT33B KRT38 KRT40 KRT6A KRTAP26-1 LDOC1 LINC00265 LITAF LURAP1 LYST MAGEB4 MAGED1 MAP3K1 MAP3K10 MAP3K7 MAPK1IP1L MARK4 MAT2A MED7 MEST MET MIF4GD MKNK1 MRFAP1L1 MTHFD1L NDC80 NEDD4 NEDD8 NEFL NF2 NMI NPAS2 NUP54 NUP62 OSBPL5 P4HA3 PAK1 PEF1 PELP1 PFKM PIK3R1 PITX1 PLD3 PMEPA1 PNMA1 POGZ PPP1R16A PPP1R7 PTCD3 RBCK1 RFX6 RHOBTB3 RINT1 RPS3A RSU1 SCAMP3 SCRN1 SF3B3 SMAD2 SMAD3 SMAD5 SNAP25 SNX1 SNX5 SNX7 SS18L1 STAM STAM2 STX11 STXBP1 SUMO1 SUN2 SYK TADA2A TASOR2 TEKT1 TFG TIMMDC1 TJP2 TLE5 TMCC2 TOM1L1 TRAF4 TRAK1 TRAP1 TRIM17 TRIM27 TRIM69 TSG101 TUBB TUBB2A UBA1 UBA52 UBB UBC UBE2I UBE4B UBQLN1 UBQLN4 USHBP1 VMP1 VPS37A VPS37B VPS37C VPS37D VPS52 ZNF302	349 interacting genes: ABHD17A ABLIM1 ADAP1 AFF4 ALKBH3 AMOTL2 ANKRD11 ANKRD36BP1 APC ARID5A ARL16 ARL4A ARNT2 ARPC3 ATP6V1C2 ATP6V1D ATP6V1G1 ATXN7 AXIN1 BAHD1 BARD1 BCAS2 BCL6 BCL6B BMS1P1 BYSL C12orf50 C1orf109 C1orf35 C2CD6 C9orf16 CBX8 CBY2 CCAR1 CCDC146 CCDC150 CCDC17 CCDC198 CCDC70 CCDC87 CCDC92 CCHCR1 CCNC CCNH CDC20B CDC5L CDC73 CDCA7 CDK1 CDK18 CDKL3 CENPP CEP55 CEP57L1 CHCHD2 CHCHD3 CINP CKB COG6 CORO1A CRMP1 CSPP1 CSTF2T CUL5 CYB5R2 DAXX DCTN4 DCX DDX6 DEUP1 DGCR6 DLGAP5 DLX6-AS1 DMTN DNM2 DOLPP1 DTX2 DVL2 EAF2 EFHC1 EGR2 EIF3G EIF4A2 EP300 ERCC3 EXOSC5 FAM110A FAM124B FAM126B FAM161A FAM184A FAM193B FAM207A FAM214A FAM50B FAM90A1 FANCG FBF1 FBXL18 FBXO28 FIP1L1 FNDC11 GATA1 GATA2 GATAD2B GCC1 GEM GFAP GGA2 GLE1 GLYCTK GMCL1 GNG5 GORASP1 GORASP2 GPANK1 GPKOW GPS2 GRAP2 GSE1 GTPBP10 GZMA GZMK HAUS1 HDAC4 HGS HOXB9 HTRA1 HYLS1 IFT20 IFT27 IHO1 IKZF3 INPP5J IQCE ISCU ITPKB ITSN2 KANK2 KANSL1 KAT5 KDM1A KIAA1217 KIFC3 KRT18 KRT6A KRT6B KRT6C LASP1 LATS1 LCOR LCP2 LENG1 LGALS3 LHX4 LIMS2 LIN7A LINGO1 LMO1 LMO2 LMO3 LMO4 LYPLA1 LYSMD1 MAB21L2 MAGOH MAGOHB MBD3 MCM10 MCM7 MFAP1 MID2 MNAT1 MORF4L1 MORF4L2 MORN3 MOS MSRB3 MTFR2 MVP MYEF2 NCF2 NDE1 NDEL1 NDN NDUFA5 NEBL NECAB2 NEFL NME7 NMRK1 NOS3 NOTCH1 NTAQ1 NUDT21 NXT2 ODF2 ORC1 PARD6B PATL1 PCM1 PIAS2 PID1 PIK3R2 PIMREG PIN1 PITX1 PKN1 PKP4 PLAAT5 POLDIP3 POM121 PPP1R16B PPP1R18 PPP2CA PQBP1 PRKAA1 PRKAB2 PRPF31 PSMA1 PSMA4 PTBP2 PTPN11 RAB1A RAB1B RAB2A RAB2B RAB33B RAB39A RAB39B RAB6A RBL1 RBM17 RBM39 RBM41 RCOR3 RGS8 RHNO1 RIBC1 RITA1 RNF135 RNF213 RNF214 RNF6 RSPH14 RSRC2 RTP5 RUSC2 RXRB SAMD4A SAP30BP SCAF8 SCEL SCNM1 SECISBP2 SELENOV SFI1 SH2D3C SH2D4A SH3GLB2 SH3RF2 SHC3 SLU7 SMARCB1 SMARCE1 SMCP SNAP47 SNF8 SNRPB SNRPB2 SNRPC SNTA1 SNW1 SPATA2 SPATA22 SRSF2 SSX2IP STAMBPL1 STK25 STK26 STN1 SUPT5H SYT6 TBC1D22B TBP TCEA2 TCEANC TCF19 TCL1A TDP2 TEAD4 TEX9 TFAP4 TFIP11 THAP7 THYN1 TLE5 TMED2 TPM1 TPX2 TRAF1 TRAF3IP2 TRAF4 TRAF5 TRIM29 TRIM42 TSC22D4 TSSC4 TSSK3 TTC23 TTC25 TTC9C TUBGCP4 TXLNA UBE2H UBE2I UBE2U UBE3C USO1 USP2 UTP14C VPS28 VPS37C WASHC3 WT1 XIAP YJU2 YTHDC1 ZBTB16 ZER1 ZFC3H1 ZFP2 ZFYVE26 ZG16B ZGPAT ZMAT1 ZMAT2 ZNF124 ZNF250 ZNF410 ZNF414 ZNF417 ZNF488 ZNF572 ZNF581 ZNF587 ZNF594 ZNF688 ZNF774
Entrez ID		9146	2801
HPRD ID		05085	03989
Ensembl ID		ENSG00000185359	ENSG00000167110
Uniprot IDs		A0A0S2Z4R4 O14964	Q08379
PDB IDs		2D3G 3F1I 3OBQ 3ZYQ 4AVX	4REY 6IW8 6IWA 6K06
Enriched GO Terms of Interacting Partners?
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