Wiki-CORONA
About
Search
Browse
Data Sources
People
Funding
Advanced Search
CCNB2 and TGFBR2
Number of citations of the paper that reports this interaction (PubMedID
9926943
)
14
Data Source:
HPRD
(in vitro, two hybrid)
CCNB2
TGFBR2
Description
cyclin B2
transforming growth factor beta receptor 2
Image
No pdb structure
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Cytoplasm
Centrosome
Cytosol
Microtubule Cytoskeleton
Membrane
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Caveola
External Side Of Plasma Membrane
Integral Component Of Membrane
Receptor Complex
Membrane Raft
Molecular Function
Protein Kinase Activity
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Protein Kinase Binding
Cadherin Binding
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta-activated Receptor Activity
Transforming Growth Factor Beta Receptor Activity, Type II
Protein Binding
ATP Binding
Glycosaminoglycan Binding
Activin-activated Receptor Activity
Mitogen-activated Protein Kinase Kinase Kinase Binding
Type I Transforming Growth Factor Beta Receptor Binding
SMAD Binding
Metal Ion Binding
Activin Binding
Transforming Growth Factor Beta Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G2/M Transition Of Mitotic Cell Cycle
In Utero Embryonic Development
Protein Phosphorylation
Mitotic Nuclear Envelope Disassembly
Regulation Of Growth
T Cell Homeostasis
Mitotic Cell Cycle Phase Transition
Thymus Development
Cell Division
Regulation Of Cell Cycle
Blood Vessel Development
Branching Involved In Blood Vessel Morphogenesis
Vasculogenesis
Response To Hypoxia
In Utero Embryonic Development
Heart Looping
Positive Regulation Of Mesenchymal Cell Proliferation
Lens Development In Camera-type Eye
Positive Regulation Of Tolerance Induction To Self Antigen
Positive Regulation Of B Cell Tolerance Induction
Positive Regulation Of T Cell Tolerance Induction
Outflow Tract Septum Morphogenesis
Membranous Septum Morphogenesis
Outflow Tract Morphogenesis
Atrioventricular Valve Morphogenesis
Tricuspid Valve Morphogenesis
Cardiac Left Ventricle Morphogenesis
Endocardial Cushion Fusion
Growth Plate Cartilage Chondrocyte Growth
Protein Phosphorylation
Receptor-mediated Endocytosis
Apoptotic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Common-partner SMAD Protein Phosphorylation
Notch Signaling Pathway
Smoothened Signaling Pathway
Gastrulation
Brain Development
Heart Development
Embryo Implantation
Aging
Response To Nutrient
Positive Regulation Of Cell Proliferation
Response To Mechanical Stimulus
Response To Glucose
Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Epithelial To Mesenchymal Transition
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Animal Organ Regeneration
Activation Of Protein Kinase Activity
Activin Receptor Signaling Pathway
Embryonic Hemopoiesis
Wound Healing
Regulation Of Cell Proliferation
Response To Drug
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Skeletal Muscle Tissue Regeneration
Response To Estrogen
Positive Regulation Of Angiogenesis
Response To Steroid Hormone
Digestive Tract Development
Positive Regulation Of Smooth Muscle Cell Proliferation
Embryonic Cranial Skeleton Morphogenesis
Positive Regulation Of NK T Cell Differentiation
Negative Regulation Of Cardiac Muscle Cell Proliferation
Pathway-restricted SMAD Protein Phosphorylation
Ventricular Septum Morphogenesis
Bronchus Morphogenesis
Trachea Formation
Mammary Gland Morphogenesis
Lung Lobe Morphogenesis
Secondary Palate Development
Response To Cholesterol
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Cell Proliferation Involved In Endocardial Cushion Morphogenesis
Superior Endocardial Cushion Morphogenesis
Inferior Endocardial Cushion Morphogenesis
Lens Fiber Cell Apoptotic Process
MiRNA Transport
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways
Polo-like kinase mediated events
Golgi Cisternae Pericentriolar Stack Reorganization
Resolution of Sister Chromatid Cohesion
Condensation of Prometaphase Chromosomes
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Initiation of Nuclear Envelope (NE) Reformation
Nuclear Pore Complex (NPC) Disassembly
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
The role of GTSE1 in G2/M progression after G2 checkpoint
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
UCH proteinases
Drugs
Glycerin
Diseases
Colorectal cancer
Loeys-Dietz syndrome (LDS)
Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS
Metabolite levels (
22916037
)
Breast cancer (
29059683
23535729
)
Cellular nuclear factor (erythroid-derived 2)-like 2 levels (
30767168
)
Cognitive decline rate in late mild cognitive impairment (
26252872
)
Estimated glomerular filtration rate (
31152163
)
Heel bone mineral density (
30598549
)
Metabolite levels (
23823483
)
Migraine (
22683712
27322543
)
Migraine - clinic-based (
23793025
)
Night sleep phenotypes (
27126917
)
Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) (
25117820
)
Systolic blood pressure (
30224653
)
Tonometry (
17903302
)
Interacting Genes
7 interacting genes:
CDK1
CDK2
CDKN1A
CKS1B
CKS2
MCM2
TGFBR2
46 interacting genes:
ACVR1
ACVRL1
AP2B1
APP
ARHGEF6
ARHGEF7
CBL
CCNB1
CCNB2
CD44
CDK1
CLU
CTNNB1
DAB2
DAXX
EIF3I
ENG
GOPC
KCNK18
NRP1
OSR1
PAK1
PDGFRA
PIK3R1
PIK3R2
PML
PSMD14
RCVRN
SMAD3
SMAD4
SMAD7
SNX6
STRAP
TCTEX1D4
TDGF1
TERT
TGFB1
TGFB1I1
TGFB2
TGFB3
TGFBR1
TGFBR3
TGFBRAP1
TRAP1
TSSK1B
ZFYVE9
Entrez ID
9133
7048
HPRD ID
04131
01823
Ensembl ID
ENSG00000157456
ENSG00000163513
Uniprot IDs
O95067
A3QNQ0
D2JYI1
P37173
PDB IDs
1KTZ
1M9Z
1PLO
2PJY
3KFD
4P7U
4XJJ
5E8V
5E8Y
5E91
5E92
5QIN
5TX4
5TY4
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?