DHX57 and CBX2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		DHX57	CBX2
Description		DExH-box helicase 57	chromobox 2
Image		No pdb structure
GO Annotations	Cellular Component	Intracellular	Euchromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	RNA Binding RNA Helicase Activity Protein Binding ATP Binding Metal Ion Binding	DNA Binding Chromatin Binding Protein Binding Methylated Histone Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Cell Differentiation Development Of Primary Sexual Characteristics
Pathways			Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases			46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Obesity-related traits ( 23251661)
Interacting Genes		10 interacting genes: CBX2 CEP44 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP9-4 ZNF473	15 interacting genes: DHX57 H3-4 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP2-4 KRTAP4-12 MDFI PCGF2 PHC2 RBMY1A1 RBMY1F RNF2 RYBP
Entrez ID		90957	84733
HPRD ID		09919	14397
Ensembl ID		ENSG00000163214	ENSG00000173894
Uniprot IDs		Q6P158	Q14781
PDB IDs			2D9U 3H91 5EPK
Enriched GO Terms of Interacting Partners?
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