UBA3 and IMPA2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		UBA3	IMPA2
Description		ubiquitin like modifier activating enzyme 3	inositol monophosphatase 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Protein-containing Complex	Cytoplasm Cytosol
	Molecular Function	Protein Binding ATP Binding Nuclear Receptor Binding NEDD8 Activating Enzyme Activity NEDD8 Transferase Activity Identical Protein Binding Protein-containing Complex Binding Protein Heterodimerization Activity	Protein Binding Inositol Monophosphate 1-phosphatase Activity Protein Homodimerization Activity Metal Ion Binding Inositol Monophosphate 3-phosphatase Activity Inositol Monophosphate 4-phosphatase Activity
	Biological Process	Cellular Protein Modification Process Proteolysis Endomitotic Cell Cycle Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Neddylation Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle	Inositol Metabolic Process Inositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Signal Transduction Inositol Phosphate Metabolic Process Phosphatidylinositol Phosphorylation Inositol Phosphate Dephosphorylation
Pathways		Dectin-1 mediated noncanonical NF-kB signaling NIK - noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of IP2, IP, and Ins in the cytosol
Drugs			Lithium
Diseases
GWAS			Diabetic peripheral neuropathy in type 2 diabetes ( 31127053) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) Stroke ( 17434096)
Interacting Genes		9 interacting genes: CHD3 CPNE2 IMPA2 KDM1A NAE1 NEDD8 UBE2D2 UBE2F UBE2M	4 interacting genes: HERPUD1 IMPA1 TNFRSF14 UBA3
Entrez ID		9039	3613
HPRD ID		04413	09329
Ensembl ID		ENSG00000144744	ENSG00000141401
Uniprot IDs		Q8TBC4	O14732
PDB IDs		1R4M 1R4N 1TT5 1Y8X 1YOV 2LQ7 2NVU 3DBH 3DBL 3DBR 3FN1 3GZN 5JJM	2CZH 2CZI 2CZK 2DDK 2FVZ
Enriched GO Terms of Interacting Partners?
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