CCNH and CCDC170

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CCNH	CCDC170
Description		cyclin H	coiled-coil domain containing 170
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor TFIIH Holo Complex Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex Transcription Factor TFIIK Complex
	Molecular Function	Protein Binding DNA-dependent ATPase Activity RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity	Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Assembly Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Phosphorylation Of RNA Polymerase II C-terminal Domain
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs
Diseases
GWAS		Bipolar disorder lithium response (continuous) or schizophrenia ( 29121268) Blood protein levels ( 29875488) Diastolic blood pressure ( 27841878) Initial pursuit acceleration ( 29064472) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Prostate cancer aggressiveness ( 25939597) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)	Bone mineral density (spine) ( 26911590) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) BRCA1/2-negative high-risk breast cancer ( 30323354) Breast cancer ( 31757997) Breast size ( 29855537 27182965) Endometriosis ( 28537267) Fractures ( 30598549) Heel bone mineral density ( 31453325 30598549 30048462 28869591) Heel bone mineral density variance ( 31453325) Number of sexual partners ( 30643258)
Interacting Genes		35 interacting genes: AR CALCOCO2 CCDC170 CCDC33 CCNC CDK2 CDK20 CDK7 CDK8 CSNK2B CTBP2 DUSP12 ERCC3 ESR1 FUBP1 GANAB GOLGA2 GTF2E2 GTF2H1 KLC3 MCM7 MTA1 NDC80 NEDD4 POLR2A POLR2B PPFIA1 PSMA1 RARB SFN SSX2IP SUPT5H TP53 TRIM8 ZNRD2	1 interacting genes: CCNH
Entrez ID		902	80129
HPRD ID		09059	10797
Ensembl ID		ENSG00000134480	ENSG00000120262
Uniprot IDs		P51946	Q8IYT3
PDB IDs		1JKW 1KXU 6O9L
Enriched GO Terms of Interacting Partners?
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