TAF1C and UFD1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		TAF1C	UFD1
Description		TATA-box binding protein associated factor, RNA polymerase I subunit C	ubiquitin recognition factor in ER associated degradation 1
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Nucleolus	Nucleus Nucleoplasm Cytosol VCP-NPL4-UFD1 AAA ATPase Complex UFD1-NPL4 Complex
	Molecular Function	RNA Polymerase I CORE Element Sequence-specific DNA Binding Protein Binding	Thiol-dependent Ubiquitin-specific Protease Activity Signaling Receptor Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Protein-containing Complex Binding ATPase Binding
	Biological Process	RNA Polymerase I Preinitiation Complex Assembly Regulation Of Transcription By RNA Polymerase I Transcription By RNA Polymerase I Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription By RNA Polymerase II Positive Regulation Of Gene Expression, Epigenetic	Skeletal System Development Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Type I Interferon Production Negative Regulation Of RIG-I Signaling Pathway Error-free Translesion Synthesis ER-associated Misfolded Protein Catabolic Process
Pathways		SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination	Translesion Synthesis by POLH Ub-specific processing proteases
Drugs
Diseases
GWAS		Autism ( 22843504) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		13 interacting genes: H2AX POLR1E RRN3 SMN1 TAF1A TAF1B TBP TK1 TP53 TRIM24 TTR UBTF UFD1	23 interacting genes: A2M AMFR ANAPC2 CHMP2A F13A1 GZMK HSPB1 IGHM LRRK2 MAP3K1 MASP1 NGFR NPLOC4 NUB1 PIK3CA PPHLN1 SNX1 TAF1C TIAM2 TP53 UBC UBXN6 VCP
Entrez ID		9013	7353
HPRD ID		05364	06778
Ensembl ID		ENSG00000103168	ENSG00000070010
Uniprot IDs		B3KUE8 Q15572	Q541A5 Q92890
PDB IDs			2YUJ 5B6C 5C1B
Enriched GO Terms of Interacting Partners?
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