USP13 and S100A9

		USP13	S100A9
Description		ubiquitin specific peptidase 13	S100 calcium binding protein A9
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GO Annotations	Cellular Component	Nucleoplasm Cytosol	Extracellular Region Extracellular Space Cell Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Junction Secretory Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Ubiquitin Binding Ubiquitin-like Protein Ligase Binding Chaperone Binding Proteasome Binding BAT3 Complex Binding Lys48-specific Deubiquitinase Activity	Calcium Ion Binding Protein Binding Microtubule Binding Zinc Ion Binding Antioxidant Activity Toll-like Receptor 4 Binding Arachidonic Acid Binding RAGE Receptor Binding
	Biological Process	Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Autophagy Cell Proliferation Regulation Of Autophagy Protein Deubiquitination Melanocyte Differentiation Protein K29-linked Deubiquitination Protein K6-linked Deubiquitination Protein Stabilization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Positive Regulation Of ERAD Pathway Maintenance Of Unfolded Protein Involved In ERAD Pathway	Cytokine Production Toll-like Receptor Signaling Pathway Leukocyte Migration Involved In Inflammatory Response Autophagy Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Cell-cell Signaling Positive Regulation Of Neuron Projection Development Antimicrobial Humoral Response Positive Regulation Of Cell Growth Neutrophil Chemotaxis Sequestering Of Zinc Ion Chemokine Production Peptidyl-cysteine S-trans-nitrosylation Modification Of Morphology Or Physiology Of Other Organism Defense Response To Bacterium Neutrophil Degranulation Innate Immune Response Positive Regulation Of Inflammatory Response Defense Response To Fungus Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytoskeleton Organization Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Neutrophil Aggregation Cellular Oxidant Detoxification Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Ub-specific processing proteases Regulation of PTEN stability and activity	RHO GTPases Activate NADPH Oxidases Regulation of TLR by endogenous ligand Neutrophil degranulation Metal sequestration by antimicrobial proteins
Drugs			Calcium Zinc
Diseases
GWAS			Asthma ( 31619474) Matrix metalloproteinase-8 levels ( 29212897)
Interacting Genes		23 interacting genes: AMFR BAG6 DVL1 FNBP1L FUNDC2 GPR160 HSP90AA1 LAPTM5 MCL1 MDC1 MRPL20 MYO15A PTEN S100A9 SIAH2 SPRR2C SYCP2 TRA2B TRIM55 TRIM63 UBC UBL4A UIMC1	9 interacting genes: CDC42 EGFR MAPK14 NCF2 PTEN S100A8 TUBA1A TUBB USP13
Entrez ID		8975	6280
HPRD ID		04666	00472
Ensembl ID		ENSG00000058056	ENSG00000163220
Uniprot IDs		A0A0A6YZ17 Q92995	P06702
PDB IDs		2L80 2LBC	1IRJ 1XK4 4GGF 4XJK 5I8N 5W1F 6DS2
Enriched GO Terms of Interacting Partners?
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