AP1M1 and CTLA4

Number of citations of the paper that reports this interaction (PubMedID 9812899)
205

Data Source:
HPRD (in vitro)

		AP1M1	CTLA4
Description		adaptor related protein complex 1 subunit mu 1	cytotoxic T-lymphocyte associated protein 4
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Cytosol Plasma Membrane Membrane Clathrin Adaptor Complex Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Specific Granule Membrane Extracellular Exosome	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Protein Complex Involved In Cell Adhesion
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Intracellular Protein Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Organization Endosome To Melanosome Transport Neutrophil Degranulation Regulation Of Defense Response To Virus By Virus	Adaptive Immune Response Immune System Process Immune Response Cellular Response To DNA Damage Stimulus Negative Regulation Of B Cell Proliferation T Cell Costimulation Negative Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways		Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation	CTLA4 inhibitory signaling RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Drugs			Ipilimumab
Diseases			Type I diabetes mellitus Graves' disease Allograft rejection Hashimoto's thyroiditis
GWAS			Alopecia areata ( 20596022 25608926) Basal cell carcinoma ( 31174203) Celiac disease ( 22057235 20190752 25920553) Celiac disease and Rheumatoid arthritis ( 26546613) Graves' disease ( 21841780) Heel bone mineral density ( 30598549) Hypothyroidism ( 27182965 22493691) Inflammatory bowel disease ( 26192919) Keratinocyte cancer (MTAG) ( 31174203) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602) Myasthenia gravis ( 25643325) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 30423114 23143596 24390342 20453842 19503088) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Subcutaneous adipose tissue ( 29178545) Type 1 diabetes ( 21829393 25751624 19430480 18978792) Ulcerative colitis ( 26192919) Vitiligo ( 27723757)
Interacting Genes		47 interacting genes: AKAP8L AP1M2 AP2B1 ARFRP1 BRCA1 CEP57L1 CORO7 CTLA4 DCX DVL2 DZIP3 EHD2 ENTR1 ETV6 FAM9B FXR2 GAK GRIN2A GRIN2B HNRNPC HOOK2 IKZF1 KIF13A KRT40 KRTAP10-3 KRTAP10-7 LAMP1 LDOC1 LZTS2 MTF1 PHC2 PIGR PNMA5 RUNDC3A SELP SLC2A4 SRPK2 SSX2IP TGOLN2 TIFA TNIP1 VAMP4 VANGL2 ZBTB14 ZBTB43 ZBTB44 ZBTB8A	15 interacting genes: AP1M1 AP2M1 BCS1L CD80 CD86 FYN JAK2 LCK LYN PIK3R1 PPP2R5A PTPN11 STAT5A STAT5B TXK
Entrez ID		8907	1493
HPRD ID		04639	00474
Ensembl ID		ENSG00000072958	ENSG00000163599
Uniprot IDs		A0A024R7K8 B3KNH5 Q59EK3 Q9BXS5	P16410
PDB IDs			1AH1 1H6E 1I85 1I8L 2X44 3BX7 3OSK 5GGV 5TRU 5XJ3
Enriched GO Terms of Interacting Partners?
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