MTMR2 and SNTA1

Number of citations of the paper that reports this interaction (PubMedID 15123239)
16

Data Source:
BioGRID (unspecified method)

		MTMR2	SNTA1
Description		myotubularin related protein 2	syntrophin alpha 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Vacuolar Membrane Cytosol Synaptic Vesicle Postsynaptic Density Axon Dendrite Early Endosome Membrane Dendritic Spine Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome Synaptic Membrane	Intracellular Cytoplasm Cytoskeleton Dystrophin-associated Glycoprotein Complex Syntrophin Complex Lateral Plasma Membrane Cell Junction Neuromuscular Junction Protein-containing Complex Sarcolemma Synapse
	Molecular Function	Phosphatidylinositol-3-phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Identical Protein Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity	Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding Sodium Channel Regulator Activity PDZ Domain Binding Ion Channel Binding Nitric-oxide Synthase Binding ATPase Binding
	Biological Process	Negative Regulation Of Receptor Internalization Protein Dephosphorylation Phosphatidylinositol Biosynthetic Process Negative Regulation Of Myelination Myelin Assembly Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Endocytosis Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Neuron Development Regulation Of Phosphatidylinositol Dephosphorylation Negative Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Maintenance Positive Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Receptor Catabolic Process	Regulation Of Heart Rate Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Sodium Ion Transmembrane Transport
Pathways		Synthesis of PIPs at the ER membrane Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy	Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Triglyceride levels x loop diuretics use interaction ( 31806883) Waist circumference adjusted for body mass index ( 28552196)	HDL cholesterol x physical activity interaction (1df test) ( 30670697) HDL cholesterol x physical activity interaction (2df test) ( 30670697)
Interacting Genes		6 interacting genes: ERBB3 ERBB4 NEFL ROR2 SBF1 SNTA1	73 interacting genes: ABCA1 ABCC4 ACTA2 ADAMTS6 ADGRB1 ADGRB2 ADGRB3 ADH5 ADRA1D ADRA2A ADRB1 AGTR2 ATP2B2 ATP6V0B C3AR1 CALM1 CD3E CNKSR2 COPB1 DGKZ DMD DTNA F8A1 FABP1 FAM189B GDA GLS GLS2 GOLGA2 GRB2 GUCY1A2 HTR2B HTR2C IL2RA IL9 ITGB5 KCNA4 KCNA5 KCNJ10 KCNJ12 KCNJ15 KCNJ4 KIF1B LMO1 MAP4 MAPK12 MAS1 MAST1 MCM7 MED8 MTMR2 NAT1 NMU NOS1 PFN2 PRLHR PSKH1 RPS6KA1 SCN1A SCN4A SCN5A SCTR SLC16A7 SLC1A7 SLC2A3 SLC6A3 SSTR1 TGFA TLX3 TRA TRBV12-3 UTRN XRCC6
Entrez ID		8898	6640
HPRD ID		04650	03009
Ensembl ID		ENSG00000087053	ENSG00000101400
Uniprot IDs		A0A024R3B7 Q13614	Q13424
PDB IDs		1LW3 1M7R 1ZSQ 1ZVR 5GNH
Enriched GO Terms of Interacting Partners?
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