PER3 and CRY1

Number of citations of the paper that reports this interaction (PubMedID 10428031)
436

Data Source:
HPRD (in vivo)

		PER3	CRY1
Description		period circadian regulator 3	cryptochrome circadian regulator 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Mitochondrion
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Protein Binding Transcription Factor Binding Kinase Binding Ubiquitin Protein Ligase Binding	Nucleotide Binding DNA Binding Double-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Binding Blue Light Photoreceptor Activity Protein Kinase Binding Phosphatase Binding Nuclear Hormone Receptor Binding Histone Deacetylase Binding E-box Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Light Stimulus Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Regulation Of Circadian Sleep/wake Cycle, Sleep Protein Stabilization	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis DNA Damage Induced Protein Phosphorylation Circadian Rhythm Response To Light Stimulus Blue Light Signaling Pathway Response To Activity Protein-chromophore Linkage Lipid Storage Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Response To Insulin Circadian Regulation Of Gene Expression Response To Glucagon Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Gluconeogenesis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Regulation Of DNA Damage Checkpoint Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Glucocorticoid Secretion
Pathways			Circadian Clock
Drugs
Diseases
GWAS		Chronotype ( 30696823) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600) Ulcerative colitis ( 28067908)	Morning person ( 30696823)
Interacting Genes		9 interacting genes: ARNTL CLOCK CRY1 CRY2 CSNK1D CSNK1E PER1 PER2 SP1	26 interacting genes: ARIH1 ARNTL BHLHE41 CBLB CLOCK CSNK1E DELEC1 FBXL3 GRN KRTAP4-12 LTBP4 MDFI NPAS2 NR1D2 PER1 PER2 PER3 PLSCR1 PPP2R1B PPP2R5D PPP2R5E SNRPD3 TIMELESS TRAF2 USP2 USP7
Entrez ID		8863	1407
HPRD ID		09138	09050
Ensembl ID		ENSG00000049246	ENSG00000008405
Uniprot IDs		A0A087WV69 A2I2N5 P56645	A2I2P0 Q16526
PDB IDs
Enriched GO Terms of Interacting Partners?
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